| Low prevalence of vitamin D deficiency in Ugandan HIV-infected patients with and without tuberculosis. | |
| | |
MedLine Citation:
|
PMID: 23044447 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: To examine whether hypovitaminosis D is a risk factor for the development of tuberculosis (TB) associated immune reconstitution inflammatory syndrome (IRIS). METHODS: We measured serum 25-hydroxyvitamin D (25D) concentrations in four groups of patients at Mulago Hospital, Kampala, Uganda: 1) patients co-infected with TB and the human immunodeficiency virus (HIV) receiving anti-tuberculosis treatment (HIV+TB+; n = 92) who did and did not develop TB-IRIS after starting antiretroviral treatment (ART), 2) HIV-infected patients without TB (HIV+TB-; n = 20) starting ART, 3) non-HIV-infected individuals with TB (HIV-TB+; n = 27), and 4) those without TB (HIV-TB-; n = 23). RESULTS: The prevalence of optimal 25D levels (>75 nmol/l) was as follows: 59% in HIV+TB+, 65% in HIV+TB-, 63% in HIV-TB+ and 35% in HIV-TB- patients. 25D concentrations decreased during the first 3 months of ART in HIV+TB+ individuals who developed IRIS (P = 0.005) and those who did not (P = 0.002), and in HIV+TB- individuals (P = 0.015); however, 25D concentration in patients who did or did not develop TB-IRIS did not differ. CONCLUSION: The prevalence of optimal vitamin D status was relatively high in HIV-infected patients with and without TB living near the equator. No difference in 25D concentrations was observed between TB-IRIS and non-IRIS. However, 25D concentrations decreased during ART. |
| | |
Authors:
|
A Conesa-Botella; O Goovaerts; M Massinga-Loembé; W Worodria; D Mazakpwe; K Luzinda; H Mayanja-Kizza; R Colebunders; L Kestens; |
Related Documents
:
|
11387807 - Measurement of fatigue in hiv-positive adults: reliability and validity of the global f... 18064557 - Religious coping and physiological, psychological, social, and spiritual outcomes in pa... 23293197 - Hepatitis c virus infection in patients with primary biliary cirrhosis. 23672107 - Livolin ameliorates elevations in alanine transaminase in hiv infected patients commenc... 10811317 - Variant forms of cholestatic diseases involving small bile ducts in adults. 11059937 - Hepatitis c virus clearance is prominent in women in an endemic area. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Volume: 16 ISSN: 1815-7920 ISO Abbreviation: Int. J. Tuberc. Lung Dis. Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-10-09 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9706389 Medline TA: Int J Tuberc Lung Dis Country: France |
Other Details:
|
Languages: eng Pagination: 1517-21 Citation Subset: IM |
Affiliation:
|
Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium; Epidemiology and Social Medicine, University of Antwerp, Antwerp, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Outcomes of Category III DOTS treatment in immunocompetent patients with tuberculosis pleural effusi...
Next Document: Tuberculosis diagnosis after bleach processing for early stage tuberculosis laboratory capacity buil...