| Low prevalence of glucose intolerance in racially mixed children with cystic fibrosis. | |
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MedLine Citation:
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PMID: 20149123 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate glucose tolerance in racially mixed Brazilian youth with cystic fibrosis (CF). METHODS: Cross-sectional study conducted between August and September 2007, at a reference service for CF, evaluating: glycated hemoglobin (HbA1c), blood glucose, and insulin levels, before and 2 h after a glucose overload. RESULTS: There were 46 patients aged between 6 yr and 16 yr and 2 months (median: 9 yr and 10 months) of whom 64% were boys. Of these, 26% were Whites; 54.4% Mulattoes; and 19.6% Blacks. HbA1c was normal in all patients. Only one participant (12-yr old) had glucose intolerance. Insulin levels ranged from 1 to 23 µIU/mL (median: 4.5 µIU/mL) at baseline and from 3.2 to 192.1 µIU/mL (median: 11 µIU/mL) after a glucose overload. Insulin resistance evaluated by the HOMA index, stratified by sex and age, was present in three patients. The ΔF508 mutation was present in only 4.3% of the sample, all of them being heterozygous. CONCLUSIONS: The low prevalence of carbohydrate intolerance in this population is probably a result of their young age. Another possibility is the low frequency of the ΔF508 mutation. Although not conclusive, these data suggest that in addition to age, the genotype:phenotype ratio may influence the development of glucose intolerance in patients with CF. |
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Authors:
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Crésio Alves; Daniela S Lima; Mauricio Cardeal; Angelica Santana |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric diabetes Volume: 11 ISSN: 1399-5448 ISO Abbreviation: Pediatr Diabetes Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100939345 Medline TA: Pediatr Diabetes Country: Denmark |
Other Details:
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Languages: eng Pagination: 493-7 Citation Subset: IM |
Copyright Information:
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© 2010 John Wiley & Sons A/S. |
Affiliation:
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Federal University of Bahia, Salvador-Bahia, Brazil. cresio.alves@uol.com.br |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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