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Low prevalence of gingival overgrowth associated to new imunossupressive protocols with cyclosporin.
MedLine Citation:
PMID:  22344340     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Gingival overgrowth (GO) is a frequent finding in patients treated with cyclosporine (CsA). This study investigated the prevalence and severity of GO in patients who received kidney transplant and CsA therapy, as well as associations with pharmacological and clinical factors. This cross-sectional study included 63 kidney transplant recipients who were treated with CsA in a university hospital. Demographic, pharmacological, and periodontal data were collected. The primary variable was GO. Independent sample t- and chi-square tests were used to compare means in groups with versusl without GO. The response rate was 86.3%. Overall, 40% of patients had some degree of GO. Eleven individuals presented GO scores > 10%, and 5 individuals reached 30%. The mean GO percentage was low (6.79 ± 15.83). Patients that were concurrently under nifedipine treatment showed a non-significant trend toward a greater prevalence of GO. Mean CsA dosage and serum levels were 3.20 ± 0.94 mg/kg/d and 156.12 ± 162.75 ng/mL, respectively. There were no statistically significant differences between patients with versusl without GO nor between the groups receiving nifedipine, no drug, or verapamil. The GO prevalence and severity rates were lower than those reported in previous studies and seemed to be independent of drug interactions.
Authors:
Luiz Augusto Wentz; Sara Cioccari Oliveira; Carlos Heitor Cunha Moreira; Cassiano Kuchenbecker Rösing
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brazilian oral research     Volume:  26     ISSN:  1807-3107     ISO Abbreviation:  Braz Oral Res     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101307187     Medline TA:  Braz Oral Res     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  64-70     Citation Subset:  D; IM    
Affiliation:
School of Dentistry, Federal University of Santa Maria, Santa Maria, RS, Brazil.
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