| Low prevalence of the APC I1307K sequence in Jewish and non-Jewish patients with inflammatory bowel disease. | |
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MedLine Citation:
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PMID: 10445854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A germline sequence alteration at codon 1307 of the APC gene (I1307K) has been reported in 6-7% of the Ashkenazi Jewish population in the United States. This alteration is believed to predispose the APC gene to a secondary mutation at the same locus, resulting in an increased risk of colorectal carcinoma. There is an increased risk of colorectal carcinoma in patients with inflammatory bowel disease (IBD), a relatively large proportion of whom are Ashkenazi Jews. We therefore sought to determine whether the I1307K sequence variant occurred in the germline DNA of IBD patients. To our surprise, we found this sequence in only two of 267 patients with IBD (0.7%), occurring in only 1.5% of Jewish IBD patients. The I1307K sequence variant was not found in 67 patients with esophageal cancer, 53 patients with gastric carcinoma (13 MSI-H and 44 MSI-negative), or ten patients with sporadic MSI-H colon cancer. These findings suggest that the I1307K sequence is relatively rare in the germline of Jewish as well as non-Jewish IBD patients. It does not appear to contribute to the increased colorectal cancer risk present in these patients. |
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Authors:
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J Yin; N Harpaz; R F Souza; T Zou; D Kong; S Wang; A L Leytin; N S Medalie; K N Smolinski; J M Abraham; A S Fleisher; S J Meltzer |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Oncogene Volume: 18 ISSN: 0950-9232 ISO Abbreviation: Oncogene Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-09-07 Completed Date: 1999-09-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8711562 Medline TA: Oncogene Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 3902-4 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Maryland School of Medicine and Baltimore VA Hospital, 21201, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Colorectal Neoplasms
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ethnology,
genetics Gene Frequency Genes, APC* Genetic Predisposition to Disease Genotype Humans Inflammatory Bowel Diseases / ethnology, genetics* Jews / genetics* Risk |
| Grant Support | |
ID/Acronym/Agency:
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CA77057/CA/NCI NIH HHS; CA78843/CA/NCI NIH HHS; DK47717/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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