Document Detail

Low power diode laser treatment using indocyanine green for eradication of esophageal varices.
MedLine Citation:
PMID:  11571685     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND STUDY AIMS: Endoscopic variceal ligation (EVL) is an alternative to sclerotherapy for the treatment of esophageal varices, but is associated with higher rates of recurrence and subsequent bleeding than sclerotherapy. To prevent recurrence of varices after EVL, we have developed a low-dose diode laser therapy combined with the injection of indocyanine green, which allows enhanced tissue absorption of the laser beam selectively around varices. In this study we investigated the efficacy and safety of this technique. PATIENTS AND METHODS: Eight patients with F2 or F3 esophageal varices were enrolled. At 1 week after EVL, indocyanine green solution (1 mg/ml) was injected submucosally around the remaining varices. A diode laser (power 10 watts) was applied to the surface from the esophagogastric junction to 5 cm above it. The spot size was kept to 5 mm in diameter. RESULTS: Laser irradiation was performed safely, without bleeding from the varices, or perforation. There were no major complications. Endoscopy 1 month later showed F0 forms in seven patients, F1 in one patient, and no red color sign in any patient. No recurrence of varices has been observed in any of the patients during the follow-up period of at least 12 months. CONCLUSION: This technique may provide a simple, safe and effective procedure, as an additional treatment to EVL, for the prevention of recurrence of esophageal varices.
S Hino; H Kakutani; K Ikeda; H Yasue; K Sumiyama; Y Uchiyama; A Kuramochi; K Matsuda; H Arakawa; M Kawamura; K Masuda; H Suzuki; T Hayashi; N Nakamura; T Arai; M Kikuchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endoscopy     Volume:  33     ISSN:  0013-726X     ISO Abbreviation:  Endoscopy     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-09-25     Completed Date:  2001-12-04     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0215166     Medline TA:  Endoscopy     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  873-5     Citation Subset:  IM    
Dept. of Endoscopy, Jikei University School of Medicine, Tokyo Japan.
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MeSH Terms
Coloring Agents / administration & dosage*
Esophageal and Gastric Varices / radiotherapy*
Indocyanine Green / administration & dosage*
Laser Therapy, Low-Level*
Middle Aged
Reg. No./Substance:
0/Coloring Agents; 3599-32-4/Indocyanine Green

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