Document Detail

Low potassium level during the first half of pregnancy is associated with lower risk for the development of gestational diabetes mellitus and severe pre-eclampsia.
MedLine Citation:
PMID:  20059438     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the association between potassium level during the first half of pregnancy and the development of gestational diabetes mellitus (GDM) and hypertensive disorders in the second half of the pregnancy.
METHODS: The study population included all registered births between the years 2001-2007. The potassium levels during the first half of pregnancy were sorted by the following groups: K < 3.5 mEq/l; K = 3.5-3.99 mEq/l; and K > or = 4 mEq/l. The linear by linear chi(2)-test was used to determine the association between potassium level during the beginning of pregnancy and pregnancy complications.
RESULTS: The study population included 8114 deliveries. A significant linear association was documented between potassium level in the first half of the pregnancy and the prevalence of GDM in the second half of the pregnancy: 6.3% in the K < 3.5 mEq/l group, 6.6% in the K = 3.5-3.99 mEq/l group and 8.2% in the K > 4 mEq/l group; (p = 0.008). A statistically significant for lower rates of severe pre-eclampsia was noted between the groups: 0.4% in the K < 3.5 mEq/l group, 0.9% in the K = 3.5-3.99 mEq/l group, 1.3% in the K = 4.0-4.99 mEq/l group and 1.5% in the K > or = 5 mEq/l group, (p = 0.027). Indeed, K > 5 mEq/l was noted as a significant risk factor for both, severe pre-eclampsia and for GDM. Using two multiple logistic regression models controlling for maternal age, potassium level was noted as an independent risk factor for both GDM and severe pre-eclampsia.
CONCLUSIONS: High potassium levels during the first half of pregnancy are associated with higher risk for the development of GDM and severe pre-eclampsia.
Talya Wolak; Ruslan Sergienko; Arnon Wiznitzer; Lior Ben Shlush; Esther Paran; Eyal Sheiner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  23     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-19     Completed Date:  2010-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  994-8     Citation Subset:  IM    
The Hypertension Unit, Soroka University Medical Center, Be'er-Sheva, Israel.
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MeSH Terms
Diabetes, Gestational / blood,  epidemiology,  etiology*
Gestational Age
Hypertension / blood,  epidemiology
Potassium / blood*
Pre-Eclampsia / blood,  epidemiology,  etiology*
Pregnancy Trimester, First / blood*
Pregnancy Trimester, Second / blood
Retrospective Studies
Risk Factors
Severity of Illness Index
Young Adult
Reg. No./Substance:

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