Document Detail


Low positive predictive value of anti-Brugia malayi IgG and IgG4 serology for the diagnosis of Wuchereria bancrofti.
MedLine Citation:
PMID:  7886763     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Enzyme-linked immunosorbent assays (ELISAs) for anti-Brugia malayi immunoglobulin (Ig) G and IgG4 were evaluated on sera from 1561 subjects in French Polynesia for the serodiagnosis of Wuchereria bancrofti filariasis, compared with the test for Onchocerca gibsoni circulating antigen (Og4C3) as a 'gold standard'. The sensitivity of the ELISA-IgG and ELISA-IgG4 assays was 90.8% and 94.5%, and the specificity was 45.9% and 50.7%. The positive predictive values were 41% and 45% respectively for an antigen prevalence rate of 30%. Thus antibody prevalences exceeded by two-fold the antigen prevalence, which itself exceeded by two-fold the prevalence of microfilaraemia.
Authors:
S Chanteau; P Glaziou; J P Moulia-Pelat; C Plichart; P Luquiaud; J L Cartel
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Transactions of the Royal Society of Tropical Medicine and Hygiene     Volume:  88     ISSN:  0035-9203     ISO Abbreviation:  Trans. R. Soc. Trop. Med. Hyg.     Publication Date:    1994 Nov-Dec
Date Detail:
Created Date:  1995-04-13     Completed Date:  1995-04-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7506129     Medline TA:  Trans R Soc Trop Med Hyg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  661-2     Citation Subset:  IM    
Affiliation:
Institut de Recherches Médicales Louis Malardé, Papeete-Tahiti, French Polynesia.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Animals
Antibodies, Helminth / blood*
Antigens, Helminth / blood
Brugia malayi / immunology*
Elephantiasis, Filarial / diagnosis*
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulin G / blood*
Middle Aged
Onchocerca / immunology
Predictive Value of Tests
Sensitivity and Specificity
Wuchereria bancrofti*
Chemical
Reg. No./Substance:
0/Antibodies, Helminth; 0/Antigens, Helminth; 0/Immunoglobulin G

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