Document Detail

Low positive end-expiratory pressure does not exacerbate nebulized-acid lung injury in dogs.
MedLine Citation:
PMID:  16015523     Owner:  NLM     Status:  MEDLINE    
It is not clear if low end-expiratory pressures contribute to ventilator-induced lung injury in large animals. We sought to determine whether ventilation with a low level of positive end-expiratory pressure (PEEP) worsens preexisting permeability lung injury in dogs. Lung injury was initiated in 20 mongrel dogs by ventilating with nebulized 3N hydrochloric acid until a lower inflection point (LIP) appeared on the respiratory system pressure-volume loop. One group of 10 dogs was then ventilated for 4 hours with PEEP set below the LIP (low PEEP), whereas the remaining group of dogs was ventilated for the same time period with similar tidal volumes but with PEEP set above the LIP (high PEEP). We found histologic evidence of reduced alveolar volumes in the low-PEEP animals. However, there were no differences in neutrophil infiltration, lung lobe weights, pulmonary capillary hemorrhage or congestion, or arterial endothelin-1 concentration between the 2 protocol groups. In conclusion, we were unable to demonstrate that ventilation with PEEP set below the LIP exacerbates hydrochloric acid-induced lung injury in dogs.
Andrew A Pellett; David A Welsh; Bennett P deBoisblanc; Gary Lipscomb; Royce W Johnson; Kevin C Lord; Michael G Levitzky
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of critical care     Volume:  20     ISSN:  0883-9441     ISO Abbreviation:  J Crit Care     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-07-14     Completed Date:  2005-08-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610642     Medline TA:  J Crit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  97-105     Citation Subset:  IM    
Department of Cardiopulmonary Science, Louisiana State University Health Sciences Center, New Orleans, 70112, USA.
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MeSH Terms
Disease Models, Animal
Hydrochloric Acid
Nebulizers and Vaporizers
Positive-Pressure Respiration*
Respiratory Distress Syndrome, Adult / chemically induced,  physiopathology*
Reg. No./Substance:
7647-01-0/Hydrochloric Acid

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