Document Detail


Low plasma glutathione levels after reperfused acute myocardial infarction are associated with late cardiac events.
MedLine Citation:
PMID:  17301597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To clarify whether an altered redox state persists in the subacute phase of myocardial infarction and if specific redox patterns are associated with later cardiac events. METHODS: Ninety-seven patients [80 men, median 63 (interquartile range, 53, 69) years] with a first acute myocardial infarction, with (53%) or without ST segment elevation, treated with successful percutaneous interventions, were tested at 5-6 days after admission for plasma alpha-tocopherol, ascorbic acid, total and reduced homocysteine, cysteine, glutathione, cysteinylglycine and blood-reduced glutathione, all assessed by high-pressure liquid chromatography. Free malondialdehyde was evaluated by gas chromatography. A subgroup of 14 patients had adjunctive blood samples within 1 h and at 72 h after angioplasty. Blood samples from 44 patients matched for age, sex, and risk factors served as controls. Patients were followed up for median 15 (interquartile range, 9, 17) months for cardiac events. RESULTS: All plasma-reduced aminothiols, vitamins and plasma total glutathione were significantly lower in myocardial infarction at 5-6 days than in controls. In the 14 myocardial infarction patients sampled repeatedly, plasma-reduced glutathione, cysteinylglycine, total glutathione, and alpha-tocopherol significantly decreased, whereas blood-reduced glutathione, total homocysteine, and cysteine significantly increased over time. During follow-up, 20 of 97 (21%) patients had adverse cardiac events. Multivariate analysis revealed that only plasma-reduced glutathione was independently associated with events (hazard ratio 0.42, 95% confidence interval 0.18-0.99, P=0.04). CONCLUSIONS: Acute myocardial infarction patients have an altered redox state at 5-6 days after successful reperfusion with respect to controls. Low plasma levels of reduced glutathione at discharge are associated with cardiac events at follow-up.
Authors:
Benedetta De Chiara; Antonio Mafrici; Jonica Campolo; Gabriella Famoso; Valentina Sedda; Marina Parolini; Giuliana Cighetti; Alessandro Lualdi; Cesare Fiorentini; Oberdan Parodi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Coronary artery disease     Volume:  18     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-15     Completed Date:  2007-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  77-82     Citation Subset:  IM    
Affiliation:
CNR Clinical Physiology Institute, Cardiology Department, Niguarda Ca' Granda Hospital, and Monzino Cardiology Center IRCCS, Department of Preclinic Sciences LITA Vialba, University of Milan, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Aged
Biological Markers / blood
Chemiluminescent Measurements
Confidence Intervals
Coronary Angiography
Dipeptides / blood
Female
Follow-Up Studies
Glutathione / blood*
Humans
Male
Middle Aged
Myocardial Infarction / blood*,  radiography,  therapy
Myocardial Reperfusion*
Oxidation-Reduction*
Prognosis
Proportional Hazards Models
Time Factors
Troponin T / blood
alpha-Tocopherol / blood
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Dipeptides; 0/Troponin T; 19246-18-5/cysteinylglycine; 59-02-9/alpha-Tocopherol; 70-18-8/Glutathione

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