Document Detail

Low plasma cholecystokinin levels in colicky infants.
MedLine Citation:
PMID:  12827004     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Cholecystokinin (CCK) plays an important role in postprandial gallbladder contraction and may also have pacifying behavioral effects, such as inducing satiety and calming in infants. The authors hypothesized that colicky infants have impaired CCK secretion, which contributes to their gallbladder hypocontractility (reported earlier) and excessive crying. METHODS: Cholecystokinin levels of 40 colicky and 37 control infants were evaluated at a mean of age 5 weeks. Plasma CCK levels were drawn before, immediately after, and 1 hour after a regular milk feeding and analyzed using radioimmunoassay (RIA). The contraction of the gallbladder was calculated using ultrasound measurements before and 1 hour after the feeding. The two-tail t test for independent samples was used to test continuous data. RESULTS: The preprandial and 1-hour postprandial plasma levels of CCK were lower in the colicky infants than in the control subjects (P < 0.05). The immediate postprandial CCK levels were also lower in the colicky infants, although this difference did not reach a statistical significance. The proportion of gallbladder contractions did not differ between the study groups. CONCLUSIONS: The authors conclude that low CCK levels in colicky infants may predispose them to excessive crying in the absence of the calming effect of CCK.
Virpi Huhtala; Liisa Lehtonen; Kerstin Uvnäs-Moberg; Heikki Korvenranta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  37     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-26     Completed Date:  2003-11-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  42-6     Citation Subset:  IM    
Department of Pediatrics, Turku University Hospital, Finland.
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MeSH Terms
Cholecystokinin / blood*
Colic / blood,  etiology,  physiopathology*
Gallbladder / ultrasonography
Postprandial Period / physiology
Reg. No./Substance:

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