Document Detail


Low plasma adiponectin levels are associated with presence of thin-cap fibroatheroma in men with stable coronary artery disease.
MedLine Citation:
PMID:  19403182     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Previous studies demonstrated the inverse association of adiponectin with coronary artery disease (CAD) especially in men with acute coronary syndrome, however their association with in vivo plaque vulnerability in stable CAD, which may be reflected by the thin-cap fibroatheroma (TCFA) prevalence, remains unknown.
METHODS: In 50 men with stable CAD, we identified TCFA with multi-vessel examination of combined use of virtual histology intravascular ultrasound (VH-IVUS) and optical coherence tomography (OCT). The definition of TCFA was described as follows; necrotic-core rich lesion (% necrotic-core >10%) without evidence of an overlying fibrous component and % plaque-volume >40% in at least 3 consecutive frames by VH-IVUS, and the thinnest fibrous-cap thickness <65 microm by OCT. The patients were divided into two groups, patients with TCFA and without TCFA, and plasma adiponectin level was compared between the groups.
RESULTS: Among 50 patients, we could observe 116 vessels (2.32+/-0.47 vessel/patient). At least one TCFA was identified in 20 patients. Patients with TCFA had significantly lower plasma adiponectin levels than patients without TCFA (P<0.0001). Furthermore, the plasma adiponectin levels in patients with multi-vessel TCFA were significantly lower than those in patients with single-vessel TCFA (P=0.049). Multivariate logistic regression analysis revealed that plasma adiponectin was the strongest predictive factor of the presence of TCFA (P=0.0007).
CONCLUSIONS: Low plasma adiponectin was associated with the presence of TCFA in men with stable CAD. This finding suggests that, in these subjects, it may be a biomarker that can be used to stratify "vulnerable patients" into risk categories.
Authors:
Takahiro Sawada; Junya Shite; Toshiro Shinke; Hiromasa Otake; Yusuke Tanino; Daisuke Ogasawara; Hiroyuki Kawamori; Hiroki Kato; Naoki Miyoshi; Naoki Yoshino; Amane Kozuki; Ken-ichi Hirata
Publication Detail:
Type:  Journal Article     Date:  2009-04-28
Journal Detail:
Title:  International journal of cardiology     Volume:  142     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-10-25     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  250-6     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009. Published by Elsevier Ireland Ltd.
Affiliation:
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome / blood,  diagnosis,  epidemiology
Adiponectin / blood
Aged
Biological Markers / blood*
Coronary Angiography
Coronary Artery Disease* / blood,  diagnosis,  epidemiology
Humans
Logistic Models
Male
Middle Aged
Predictive Value of Tests
Prevalence
ROC Curve
Risk Factors
Tomography, Optical Coherence
Ultrasonography, Interventional
Chemical
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin; 0/Biological Markers

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