Document Detail


Low plasma RANTES levels are an independent predictor of cardiac mortality in patients referred for coronary angiography.
MedLine Citation:
PMID:  17255538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Our objective was to evaluate the prognostic value of baseline plasma RANTES levels in patients with known or suspected coronary artery disease. RANTES is a chemokine produced by a variety of cell types including platelets that has been implicated in atherosclerosis. METHODS AND RESULTS: Baseline plasma RANTES levels were measured in 389 male patients undergoing coronary angiography at a Veterans Affairs Medical Center. The patients were followed-up prospectively for the occurrence of cardiac mortality and myocardial infarction. Follow-up data at 24 months were available for 97% of patients. In the entire cohort of patients, low baseline RANTES levels were an independent predictor of cardiac mortality. For cardiac death at 24 months, the survival rate was 87.3% in the lowest tertile of RANTES values, compared with 94% in the upper 2 tertiles combined (P=0.0298 by log rank test). Furthermore, when patients were risk-stratified into those with and without an acute coronary syndrome, RANTES was an independent predictor of both cardiac mortality and myocardial infarction in those without an acute coronary syndrome. Finally, RANTES was also an independent predictor of cardiac mortality in the diabetic subset. CONCLUSIONS: In a cohort of male patients undergoing coronary angiography, low baseline plasma RANTES levels are an independent predictor of cardiac mortality.
Authors:
Erdal Cavusoglu; Calvin Eng; Vineet Chopra; Luther T Clark; David J Pinsky; Jonathan D Marmur
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Publication Detail:
Type:  Journal Article     Date:  2007-01-25
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  27     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-22     Completed Date:  2007-04-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  929-35     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Department of Medicine, SUNY Downstate Medical Center, 450 Clarkson Avenue, Box 1257, Brooklyn, NY 11203-2098, USA. ECavusoglu@aol.com
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aged
Chemokine CCL5 / blood*
Cohort Studies
Coronary Angiography*
Coronary Artery Disease / blood*,  complications,  mortality,  radiography*
Death*
Diabetic Angiopathies / blood,  mortality,  radiography
Follow-Up Studies
Humans
Incidence
Kaplan-Meiers Estimate
Male
Middle Aged
Myocardial Infarction / epidemiology,  etiology
Predictive Value of Tests
Prospective Studies
Referral and Consultation*
Syndrome
Time Factors
Chemical
Reg. No./Substance:
0/Chemokine CCL5

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