Document Detail

Low physical activity is associated with proinflammatory high-density lipoprotein and increased subclinical atherosclerosis in women with systemic lupus erythematosus.
MedLine Citation:
PMID:  20191526     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the association between physical activity, functional activity of high-density lipoprotein (HDL), and subclinical cardiovascular disease in patients with systemic lupus erythematosus (SLE).
METHODS: A total of 242 SLE patients (all women) participated in this cross-sectional study from February 2004 to February 2008. Carotid plaque and intima-media thickness (IMT), antioxidant function of HDL, and traditional cardiac risk factors were measured. Physical activity was assessed from self-reports by calculating the metabolic equivalents (METS) per week and by the physical function domain of the Medical Outcomes Study Short Form 36 (SF-36). Data were analyzed using bivariate and multivariate regression analyses.
RESULTS: Number of METS per week spent performing strenuous exercise was negatively correlated with IMT (r = -0.4, P = 0.002) and number of plaques (r = -0.30, P = 0.0001). Physical function as assessed by the SF-36 was also negatively correlated with IMT (r = -0.14, P = 0.03) and number of plaques (r = -0.14, P = 0.04). In multivariate analyses, number of strenuous exercise METS was significantly associated with IMT (t = -2.2, P = 0.028) and number of plaques (t = -2.5, P = 0.014) when controlling for markers of SLE disease activity and damage, but not after controlling for traditional cardiac risk factors. Low physical activity, defined as <225 total METS per week, was associated with the presence of proinflammatory HDL (P = 0.03).
CONCLUSION: Low physical activity is associated with increased subclinical atherosclerosis and proinflammatory HDL in patients with SLE. Increased strenuous exercise may reduce the risk of atherosclerosis in SLE.
Elizabeth R Volkmann; Jennifer M Grossman; Lori J Sahakian; Brian J Skaggs; John FitzGerald; Nagesh Ragavendra; Christina Charles-Schoeman; Weiling Chen; Alan Gorn; George Karpouzas; Michael Weisman; Daniel J Wallace; Bevra H Hahn; Maureen McMahon
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arthritis care & research     Volume:  62     ISSN:  2151-4658     ISO Abbreviation:  Arthritis Care Res (Hoboken)     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-01     Completed Date:  2010-04-07     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  101518086     Medline TA:  Arthritis Care Res (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  258-65     Citation Subset:  IM    
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MeSH Terms
Atherosclerosis / complications*
Carotid Arteries / ultrasonography
Carotid Stenosis / complications
Inflammation Mediators / blood*
Lipoproteins, LDL / blood*
Lupus Erythematosus, Systemic / blood,  complications*,  physiopathology*,  ultrasonography
Middle Aged
Motor Activity*
Tunica Intima / ultrasonography
Tunica Media / ultrasonography
Grant Support
1K23AR053864-01A1/AR/NIAMS NIH HHS; K23 AR053864/AR/NIAMS NIH HHS; K23 AR053864-01A1/AR/NIAMS NIH HHS
Reg. No./Substance:
0/Inflammation Mediators; 0/Lipoproteins, LDL

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