Document Detail

Low peritoneal and systemic inflammatory response after laparoscopy-assisted gastrectomy compared to open gastrectomy.
MedLine Citation:
PMID:  21661448     Owner:  NLM     Status:  In-Process    
BACKGROUND/AIMS: Peritoneal immune response as well as systemic response was objectively evaluated in laparoscopy-assisted distal gastrectomy (LADG) compared to open distal gastrectomy (ODG).
METHODOLOGY: A total of 42 patients with gastric cancer were enrolled, with 23 undergoing LADG and 19 ODG. We evaluated the levels of IL-6 in peritoneal drain fluid, serum C-reactive protein (CRP), white blood cells (WBC), and the postoperative presence of systemic inflammatory response syndrome (SIRS).
RESULTS: The serum CRP level was significantly higher in the ODG group than in the LADG group (p=0.007) on postoperative day (POD) 1. WBC counts showed no statistically significant difference between the two groups (p=0.105). The rate of cases exhibiting SIRS was significantly higher in the ODG group than in the LADG group (p<0.001). The IL-6 level of drain fluid was significantly higher in the ODG group than the LADG group (p<0.01) on POD1. Although weak correlation between IL-6 on POD1 and blood loss (R=0.38, p=0.0154) was observed, no significant correlation between IL-6 and operation time was noted.
CONCLUSIONS: LADG seems to be a lesser traumatic approach for the treatment of gastric cancer.
Toshiyuki Natsume; Hiroshi Kawahira; Hideki Hayashi; Yoshihiro Nabeya; Takashi Akai; Daisuke Horibe; Kiyohiko Shuto; Yasunori Akutsu; Kazuyuki Matsushita; Fumio Nomura; Hisahiro Matsubara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  58     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2011 Mar-Apr
Date Detail:
Created Date:  2011-06-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  659-62     Citation Subset:  IM    
Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
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