Document Detail


Low pH enhances response of thin muscle afferents to mechanical stimuli.
MedLine Citation:
PMID:  20217373     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined whether acidic buffer sensitizes thin muscular afferents to mechanical stimulus using single-fiber recording. The EDL muscle with the common peroneal nerve attached was excised from 17-male SD rats under pentobarbital anesthesia. After identifying single thin afferent fibers, mechanical stimulus was applied to their receptive fields using a servo-controlled mechanical stimulator before and after pH 6.2-solution was applied to the receptive field. The effect of pH 7.4-solution was similarly examined as a control. Application of pH 7.4-solution did not induce any change in the mechanical threshold or increase in the number of discharges evoked during stimulation over the number of spontaneous discharges (response magnitude). However, pH 6.2-solution significantly lowered the mechanical threshold and increased the response magnitude, suggesting that the mechanical sensitivity of thin muscle afferents was augmented by exposure to acidic pH, which is seen during exercise. This change could be involved in respiratory control during exercise.
Authors:
Norio Hotta; Toru Taguchi; Kazue Mizumura
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  669     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  315-8     Citation Subset:  IM    
Affiliation:
Department of Neuroscience II, Division of Stress Recognition and Response, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics
Buffers
Hydrogen-Ion Concentration
Male
Mechanical Processes*
Muscle Fibers, Skeletal / physiology
Muscle, Skeletal / physiology*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Buffers

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