| Low-osmolar monomeric versus iso-osmolar dimeric contrast media: An intra-individual comparison in CT angiography using an animal model. | |
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MedLine Citation:
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PMID: 21501406 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Introduction: The aim of this study was to compare intra-individual contrast enhancement in multidetector-row computed tomography using the low-osmolar monomeric iopromide 300 and the iso-osmolar dimeric iodixanol 320. Methods: Repeated computed tomography scanning of the chest of five pigs was performed under standardised conditions using iopromide 300 (300 mg I/mL) and iodixanol 320 (320 mg I/mL) with an identical iodine delivery rate of 1.5 g I/sec and a total iodine dose of 300 mg/kg body weight. Time-enhancement curves were computed, and pulmonary and aortic peak enhancement, time-to-peak and plateau time above 300 Hounsfield units (HU) were analysed. Results: Intra-individual comparison revealed no statistically significant differences in contrast enhancement between the iopromide 300 and iodixanol 320 in the pulmonary artery and the aorta (620 vs 552 HU; P = 0.13). There was no significant difference between the two CM in the plateau time at the pulmonary artery and the aorta (P = 0.75 and P = 0.24, respectively). Aortic peak time was significantly earlier with iopromide 300 than with iodixanol 320 (P = 0.004). Conclusions: Low-osmolar monomeric and iso-osmolar dimeric CM provide a similar and suitable vascular contrast enhancement. |
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Authors:
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Florian F Behrendt; Hubertus Pietsch; Gregor Jost; Sebastian Keil; Felix M Mottaghy; Rolf W Günther; Andreas H Mahnken |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of medical imaging and radiation oncology Volume: 55 ISSN: 1754-9485 ISO Abbreviation: J Med Imaging Radiat Oncol Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101469340 Medline TA: J Med Imaging Radiat Oncol Country: Australia |
Other Details:
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Languages: eng Pagination: 170-5 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Journal of Medical Imaging and Radiation Oncology © 2011 The Royal Australian and New Zealand College of Radiologists. |
Affiliation:
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Departments of Radiology Nuclear Medicine, Aachen University Hospital Applied Medical Engineering, Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Aachen Bayer Schering Pharma AG, Berlin, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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