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Low-osmolar monomeric versus iso-osmolar dimeric contrast media: An intra-individual comparison in CT angiography using an animal model.
MedLine Citation:
PMID:  21501406     Owner:  NLM     Status:  In-Data-Review    
Introduction: The aim of this study was to compare intra-individual contrast enhancement in multidetector-row computed tomography using the low-osmolar monomeric iopromide 300 and the iso-osmolar dimeric iodixanol 320. Methods: Repeated computed tomography scanning of the chest of five pigs was performed under standardised conditions using iopromide 300 (300 mg I/mL) and iodixanol 320 (320 mg I/mL) with an identical iodine delivery rate of 1.5 g I/sec and a total iodine dose of 300 mg/kg body weight. Time-enhancement curves were computed, and pulmonary and aortic peak enhancement, time-to-peak and plateau time above 300 Hounsfield units (HU) were analysed. Results: Intra-individual comparison revealed no statistically significant differences in contrast enhancement between the iopromide 300 and iodixanol 320 in the pulmonary artery and the aorta (620 vs 552 HU; P = 0.13). There was no significant difference between the two CM in the plateau time at the pulmonary artery and the aorta (P = 0.75 and P = 0.24, respectively). Aortic peak time was significantly earlier with iopromide 300 than with iodixanol 320 (P = 0.004). Conclusions: Low-osmolar monomeric and iso-osmolar dimeric CM provide a similar and suitable vascular contrast enhancement.
Florian F Behrendt; Hubertus Pietsch; Gregor Jost; Sebastian Keil; Felix M Mottaghy; Rolf W Günther; Andreas H Mahnken
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical imaging and radiation oncology     Volume:  55     ISSN:  1754-9485     ISO Abbreviation:  J Med Imaging Radiat Oncol     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101469340     Medline TA:  J Med Imaging Radiat Oncol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  170-5     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Journal of Medical Imaging and Radiation Oncology © 2011 The Royal Australian and New Zealand College of Radiologists.
Departments of Radiology Nuclear Medicine, Aachen University Hospital Applied Medical Engineering, Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Aachen Bayer Schering Pharma AG, Berlin, Germany.
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