Document Detail


Low molecular weight polyethylene glycol induces chromosome aberrations in Chinese hamster cells cultured in vitro.
MedLine Citation:
PMID:  11971999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human population is widely exposed to polyethylene glycol (PEG) and its chemical derivatives, which are widely used as vehicles or co-solvents in many pharmaceutical and cosmetic preparations. However, PEG polymers of low molecular weight differ significantly from polymers of higher molecular weight in their physico-chemical properties, biological effects on cell permeability and their absorption and excretion, as well as their higher toxicity and possibly genotoxicity. In the present study we have analysed the induction of chromosome aberrations by the low molecular weight PEG polymers tetraethylene glycol (TEG), PEG 200 and PEG 400 in a Chinese hamster epithelial liver (CHEL) cell line, which retains sufficient metabolic capability to activate different promutagens and procarcinogens. The results indicate that in CHEL cells only TEG and PEG 200 are clastogenic. Parallel experiments performed in CHO cells in the presence and absence of rat liver S9 mix showed significant increases in chromosomal aberrations only in cultures treated with TEG in the presence of rat liver S9, indicating that low molecular weight polymers need to be activated to exert their genotoxic activity.
Authors:
Olga Biondi; Salvatore Motta; Pasquale Mosesso
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutagenesis     Volume:  17     ISSN:  0267-8357     ISO Abbreviation:  Mutagenesis     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-04-24     Completed Date:  2002-12-06     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8707812     Medline TA:  Mutagenesis     Country:  England    
Other Details:
Languages:  eng     Pagination:  261-4     Citation Subset:  IM    
Affiliation:
Università di Catania, Dipartimento di Biologia Animale, Via Androne 81, 95124 Catania, Italy. biondol@unict.it
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MeSH Terms
Descriptor/Qualifier:
Animals
CHO Cells
Chromosome Aberrations*
Chromosomes / drug effects*
Cricetinae
Liver / drug effects
Mutagens
Polyethylene Glycols*
Polymers
Rats
Chemical
Reg. No./Substance:
0/Mutagens; 0/Polyethylene Glycols; 0/Polymers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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