| Low-molecular weight nucleic acids in the blood of rats with Zajdela's hepatoma. | |
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MedLine Citation:
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PMID: 728891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The phenolic method was employed to isolate 2--3 microgram/ml of nucleic acid from rat blood serum. Electrophoresis in an 8% polyacrylamide gel revealed 3 fractions corresponding to 7--9S RNA, and a highly polymer material retained at the beginning of the gel. The blood of the rats with transplanted Zajdela's hepatoma, pre-treated with CCl4, contained an immunodepressive nucleic factor (5S DNA) undetected in healthy animals. This factor may contribute to the suppression of antitumor immunity. The nucleic factor was not detected following treatment with CCl4 alone. It is suggested that the liver hinders nucleic factor transfer from the tumor environs into the blood. |
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Authors:
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A S Belokhvostov; N K Zelenkova |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer letters Volume: 5 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 1978 Dec |
Date Detail:
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Created Date: 1979-03-28 Completed Date: 1979-03-28 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 351-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Tetrachloride / pharmacology DNA, Neoplasm / blood*, immunology Immunosuppression Liver / drug effects Liver Neoplasms, Experimental / blood*, immunology Male Molecular Weight RNA, Neoplasm / blood* Rats |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm; 0/RNA, Neoplasm; 56-23-5/Carbon Tetrachloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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