Document Detail

Low-molecular-weight heparin and other antithrombotic agents in the setting of a fast-track revascularization in unstable coronary artery disease.
MedLine Citation:
PMID:  11251354     Owner:  NLM     Status:  MEDLINE    
Revascularization procedures and particularly percutaneous transluminal coronary angioplasty are being performed more and more often in patients with unstable coronary artery disease, despite the fact that these procedures are known to carry a higher risk in such patients than in those with stable disease. This article reviews studies that have investigated the potential of modern antithrombotic therapy -- low-molecular-weight heparin, anti-Xa agents, direct antithrombin inhibitors and glycoprotein IIb/IIIa inhibitors -- to reduce the post-procedural event rate in such patients. The results are promising.
J P Bassand
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Haemostasis     Volume:  30 Suppl 2     ISSN:  0301-0147     ISO Abbreviation:  Haemostasis     Publication Date:  2000  
Date Detail:
Created Date:  2001-03-19     Completed Date:  2001-07-05     Revised Date:  2013-05-24    
Medline Journal Info:
Nlm Unique ID:  0371574     Medline TA:  Haemostasis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  114-21; discussion 106-7     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel
Department of Cardiology, University Hospital Jean-Minjoz, Besançon, France.
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MeSH Terms
Angina, Unstable / complications,  drug therapy*,  mortality,  surgery
Angioplasty, Balloon, Coronary
Antibodies, Monoclonal / therapeutic use
Anticoagulants / administration & dosage,  therapeutic use*
Aspirin / administration & dosage,  therapeutic use
Clinical Trials as Topic
Combined Modality Therapy
Diabetes Complications
Drug Therapy, Combination
Factor Xa / antagonists & inhibitors
Heparin, Low-Molecular-Weight / administration & dosage,  therapeutic use*
Hirudin Therapy
Hirudins / administration & dosage,  analogs & derivatives
Immunoglobulin Fab Fragments / therapeutic use
Myocardial Revascularization*
Oligosaccharides / administration & dosage,  therapeutic use
Peptide Fragments / administration & dosage,  therapeutic use
Peptides / therapeutic use
Platelet Aggregation Inhibitors / administration & dosage,  therapeutic use
Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors
Postoperative Complications / prevention & control
Randomized Controlled Trials as Topic
Recombinant Proteins / administration & dosage,  therapeutic use
Risk Factors
Thrombocytopenia / chemically induced
Thrombosis / prevention & control*
Time Factors
Treatment Outcome
Tyrosine / analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Anticoagulants; 0/Heparin, Low-Molecular-Weight; 0/Hirudins; 0/Immunoglobulin Fab Fragments; 0/Oligosaccharides; 0/PENTA; 0/Peptide Fragments; 0/Peptides; 0/Platelet Aggregation Inhibitors; 0/Platelet Glycoprotein GPIIb-IIIa Complex; 0/Recombinant Proteins; 0/eptifibatide; 128270-60-0/bivalirudin; 144494-65-5/tirofiban; 50-78-2/Aspirin; 55520-40-6/Tyrosine; EC Xa; X85G7936GV/abciximab

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