Document Detail

Low molecular weight heparin in the treatment of severe acute pancreatitis: a multiple centre prospective clinical study.
MedLine Citation:
PMID:  19423455     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the effect of low molecular weight heparin (LMWH) in the treatment of severe acute pancreatitis (SAP). METHODS: A total of 265 SAP patients were randomly divided into two groups: firstly, the conventional treatment group (C group, n = 130; and secondly the conventional treatment plus the LMWH treatment group (LT group, n = 135). The clinical parameters, laboratory parameters and computed tomography (CT) score of pancreatic necrosis (CTSPN) in the two groups were compared. RESULTS: On admission, all the clinical parameters, laboratory parameters and CTSPN in the two groups were not significantly different (p > 0.05). However, after treatment, in LT group, the clinical presentation improvement rate and laboratory parameters improvement were significantly higher than those in C group (p < 0.05-0.01), and the acute physiology and chronic health evaluation (APACHE) II score, complication rate, mortality and mean hospital stay in LT group were obviously lower than those in C group (p < 0.05-0.01). The CT score in LT group was much lower than that in C group (p < 0.05). Two weeks after treatment FBI decreased obviously in C group, but not in LT group, and no haemorrhagic complications occurred. CONCLUSIONS: LMWH can enhance the effect of conventional treatment for SAP, and can markedly decrease the mortality of SAP. LMWH is a simple, safe, economic and effective method for treatment of SAP. It is can be used in every hospital.
Xin-Sheng Lu; Fu Qiu; Jie-Qin Li; Qin-Qiao Fan; Ri-Guang Zhou; Yu-Hang Ai; Kai-Cheng Zhang; Yi-Xiong Li
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Asian journal of surgery / Asian Surgical Association     Volume:  32     ISSN:  1015-9584     ISO Abbreviation:  Asian J Surg     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-08     Completed Date:  2009-08-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8900600     Medline TA:  Asian J Surg     Country:  China    
Other Details:
Languages:  eng     Pagination:  89-94     Citation Subset:  IM    
Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China.
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MeSH Terms
Acute Disease
Anticoagulants / therapeutic use*
Heparin, Low-Molecular-Weight / therapeutic use*
Middle Aged
Multiple Organ Failure / epidemiology
Pancreatitis / drug therapy*
Prospective Studies
Young Adult
Reg. No./Substance:
0/Anticoagulants; 0/Heparin, Low-Molecular-Weight

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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