| Low molecular weight heparin in the treatment of severe acute pancreatitis: a multiple centre prospective clinical study. | |
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MedLine Citation:
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PMID: 19423455 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the effect of low molecular weight heparin (LMWH) in the treatment of severe acute pancreatitis (SAP). METHODS: A total of 265 SAP patients were randomly divided into two groups: firstly, the conventional treatment group (C group, n = 130; and secondly the conventional treatment plus the LMWH treatment group (LT group, n = 135). The clinical parameters, laboratory parameters and computed tomography (CT) score of pancreatic necrosis (CTSPN) in the two groups were compared. RESULTS: On admission, all the clinical parameters, laboratory parameters and CTSPN in the two groups were not significantly different (p > 0.05). However, after treatment, in LT group, the clinical presentation improvement rate and laboratory parameters improvement were significantly higher than those in C group (p < 0.05-0.01), and the acute physiology and chronic health evaluation (APACHE) II score, complication rate, mortality and mean hospital stay in LT group were obviously lower than those in C group (p < 0.05-0.01). The CT score in LT group was much lower than that in C group (p < 0.05). Two weeks after treatment FBI decreased obviously in C group, but not in LT group, and no haemorrhagic complications occurred. CONCLUSIONS: LMWH can enhance the effect of conventional treatment for SAP, and can markedly decrease the mortality of SAP. LMWH is a simple, safe, economic and effective method for treatment of SAP. It is can be used in every hospital. |
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Authors:
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Xin-Sheng Lu; Fu Qiu; Jie-Qin Li; Qin-Qiao Fan; Ri-Guang Zhou; Yu-Hang Ai; Kai-Cheng Zhang; Yi-Xiong Li |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Asian journal of surgery / Asian Surgical Association Volume: 32 ISSN: 1015-9584 ISO Abbreviation: Asian J Surg Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-05-08 Completed Date: 2009-08-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8900600 Medline TA: Asian J Surg Country: China |
Other Details:
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Languages: eng Pagination: 89-94 Citation Subset: IM |
Affiliation:
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Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China. xinshenglv@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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APACHE Acute Disease Adolescent Adult Aged Anticoagulants / therapeutic use* Child Female Heparin, Low-Molecular-Weight / therapeutic use* Humans Male Middle Aged Multiple Organ Failure / epidemiology Pancreatitis / drug therapy* Prospective Studies Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Heparin, Low-Molecular-Weight |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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