Document Detail


Low molecular weight heparin (Alfa LHWH) compared with unfractionated heparin in prevention of deep-vein thrombosis after hip fractures.
MedLine Citation:
PMID:  2556484     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Efficacy and safety of a low molecular weight heparin (Alfa LMWH) was compared with unfractionated heparin (UFH) in the prevention of post-operative venous thromboembolism after hip fractures. Forty-nine patients were randomized to treatment with Alfa LMWH 7500 anti-Xa coagulometric units twice daily or with UFH 5000 IU t.i.d. Screening for thrombosis was performed with 125-I-fibrinogen leg scanning and strain-gauge plethysmography. Positive results were confirmed by venography. Five patients in the Alfa LMWH group (20 per cent) developed venographycally proven deep vein thrombosis (DVT) versus seven (29 per cent) in the UFH group. One pulmonary embolism and two deaths occurred in the UFH group and none in the LMWH group. No differences in haemorrhagic complications and blood loss indices were observed. Alfa LMWH appears to be a promising drug for prevention of venous thromboembolism after orthopaedic surgery. A "flexible" schedule of administration is proposed on the basis of the results of plasma anti-Xa assays.
Authors:
M Pini; A Tagliaferri; C Manotti; F Lasagni; E Rinaldi; A G Dettori
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International angiology : a journal of the International Union of Angiology     Volume:  8     ISSN:  0392-9590     ISO Abbreviation:  Int Angiol     Publication Date:    1989 Jul-Sep
Date Detail:
Created Date:  1990-01-22     Completed Date:  1990-01-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8402693     Medline TA:  Int Angiol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  134-9     Citation Subset:  IM    
Affiliation:
Vth Medical Department, Ospedale Maggiore, Parma, Italy.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Blood Coagulation Tests
Female
Heparin / administration & dosage*,  adverse effects
Heparin, Low-Molecular-Weight / administration & dosage*,  adverse effects
Hip Fractures / surgery*
Humans
Male
Postoperative Complications / prevention & control*
Randomized Controlled Trials as Topic
Thrombophlebitis / prevention & control*
Chemical
Reg. No./Substance:
0/Heparin, Low-Molecular-Weight; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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