Document Detail

Low molecular weight IgM in rheumatoid arthritis and other rheumatic diseases.
MedLine Citation:
PMID:  6972766     Owner:  NLM     Status:  MEDLINE    
Low molecular weight (LMW) IgM was measured in the serum and synovial fluid of patients with rheumatoid arthritis (RA) and other rheumatic diseases. High levels were seen in RA, particularly in rheumatoid vasculitis and Felty's syndrome, and significant correlations occurred between LMW IgM and the rheumatoid factor (RF) level and other indices that reflected active or severe disease. LMW IgM-RF, measured by radioimmunoassay in those column fractions containing LMW IgM, correlated significantly with LMW IgM (P less than 0.005); preliminary experiments suggested that in some sera, a considerable proportion of the LMW IgM consisted of LMW IgM-RF. We conclude that LMW IgM and LMW IgM-RF may have important implications in the immunopathogenesis of RA and other rheumatic diseases.
P J Roberts-Thomson; R M Wernick; M Ziff
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  24     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  1981 Jun 
Date Detail:
Created Date:  1981-08-10     Completed Date:  1981-08-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  795-802     Citation Subset:  AIM; IM    
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MeSH Terms
Antigen-Antibody Complex / immunology
Arthritis / blood
Arthritis, Rheumatoid / immunology*
Immunoglobulin M / analysis*,  blood
Lupus Erythematosus, Systemic / blood
Middle Aged
Molecular Weight
Nephelometry and Turbidimetry
Rheumatic Diseases / immunology*
Rheumatoid Factor / analysis
Synovial Fluid / analysis
Grant Support
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Immunoglobulin M; 9009-79-4/Rheumatoid Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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