Document Detail

Low-moderate prenatal alcohol exposure and risk to child behavioural development: a prospective cohort study.
MedLine Citation:
PMID:  20528867     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the association of fetal alcohol exposure during pregnancy with child and adolescent behavioural development. DESIGN: The Western Australian Pregnancy Cohort (Raine) Study recruited 2900 pregnancies (1989-91) and the 14-year follow up was conducted between 2003 and 2006. SETTING: Tertiary obstetric hospital in Perth, Western Australia. POPULATION: The women in the study provided data at 18 and 34 weeks of gestation on weekly alcohol intake: no drinking, occasional drinking (up to one standard drink per week), light drinking (2-6 standard drinks per week), moderate drinking (7-10 standard drinks per week), and heavy drinking (11 or more standard drinks per week). Methods Longitudinal regression models were used to analyse the effect of prenatal alcohol exposure on Child Behaviour Checklist (CBCL) scores over 14 years, assessed by continuous z-scores and clinical cutoff points, after adjusting for confounders. MAIN OUTCOME MEASURE: Their children were followed up at ages 2, 5, 8, 10 and 14 years. The CBCL was used to measure child behaviour. RESULTS: Light drinking and moderate drinking in the first 3 months of pregnancy were associated with child CBCL z-scores indicative of positive behaviour over 14 years after adjusting for maternal and sociodemographic characteristics. These changes in z-score indicated a clinically meaningful reduction in total, internalising and externalising behavioural problems across the 14 years of follow up. CONCLUSIONS: Our findings do not implicate light-moderate consumption of alcohol in pregnancy as a risk factor in the epidemiology of child behavioural problems.
M Robinson; W H Oddy; N J McLean; P Jacoby; C E Pennell; N H de Klerk; S R Zubrick; F J Stanley; J P Newnham
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2010-05-28
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  117     ISSN:  1471-0528     ISO Abbreviation:  BJOG     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-07     Completed Date:  2010-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  1139-50     Citation Subset:  AIM; IM    
Telethon Institute for Child Health Research, Centre for Child Health Research, Perth, Australia.
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MeSH Terms
Alcohol Drinking / adverse effects*
Child Behavior Disorders / epidemiology*
Child, Preschool
Prenatal Exposure Delayed Effects / epidemiology*
Prospective Studies
Randomized Controlled Trials as Topic
Risk Factors
Western Australia / epidemiology
Young Adult
Comment In:
BJOG. 2010 Aug;117(9):1150-1   [PMID:  20617540 ]
BJOG. 2010 Nov;117(12):1563-4; author reply 1564-5   [PMID:  20937077 ]
BJOG. 2010 Aug;117(9):1151-2   [PMID:  20617541 ]

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