Document Detail


Low maternal serum levels of pregnancy-associated plasma protein-A during the first trimester are associated with subsequent preterm delivery with preterm premature rupture of membranes.
MedLine Citation:
PMID:  17962103     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the relationship between the first-trimester maternal serum pregnancy-associated plasma protein-A (PAPP-A) levels and pregnancies complicated by preterm delivery. MATERIALS AND METHODS: The correlation between PAPP-A levels and gestational age at delivery was analyzed by linear regression. The probabilities of low PAPP-A multiples of the median (MoM) levels between preterm delivery and control population were analyzed by logit model. RESULTS: A positive correlation was noted between the first-trimester PAPP-A MoM levels and gestational age at delivery between 34-38 weeks (p < 0.001). Lower PAPP-A MoM level had a significantly higher likelihood of preterm delivery (p < 0.05). When preterm premature rupture of membranes (PPROM) and preterm labor (PTL) were analyzed separately, there was an increasing likelihood of PPROM with decreasing PAPP-A MoM levels (p < 0.05), but not for PTL with intact membranes. CONCLUSION: Low maternal serum PAPP-A levels during the first trimester may reflect a trophoblast invasion defect in the maternal-fetal interface, resulting in subsequent preterm delivery, particularly in those of PPROM.
Authors:
Bo-Quing She; Su-Chee Chen; Fa-Kung Lee; Mei-Leng Cheong; Ming-Song Tsai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Taiwanese journal of obstetrics & gynecology     Volume:  46     ISSN:  1875-6263     ISO Abbreviation:  -     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-10-26     Completed Date:  2007-12-18     Revised Date:  2007-12-28    
Medline Journal Info:
Nlm Unique ID:  101213819     Medline TA:  Taiwan J Obstet Gynecol     Country:  China    
Other Details:
Languages:  eng     Pagination:  242-7     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Female
Fetal Membranes, Premature Rupture / blood*,  etiology
Gestational Age
Humans
Linear Models
Pregnancy
Pregnancy Trimester, First / blood*
Pregnancy-Associated Plasma Protein-A / metabolism*
Premature Birth / blood*,  etiology
Probability
Chemical
Reg. No./Substance:
EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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