| Low maternal serum levels of pregnancy-associated plasma protein-A during the first trimester are associated with subsequent preterm delivery with preterm premature rupture of membranes. | |
| | |
MedLine Citation:
|
PMID: 17962103 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To assess the relationship between the first-trimester maternal serum pregnancy-associated plasma protein-A (PAPP-A) levels and pregnancies complicated by preterm delivery. MATERIALS AND METHODS: The correlation between PAPP-A levels and gestational age at delivery was analyzed by linear regression. The probabilities of low PAPP-A multiples of the median (MoM) levels between preterm delivery and control population were analyzed by logit model. RESULTS: A positive correlation was noted between the first-trimester PAPP-A MoM levels and gestational age at delivery between 34-38 weeks (p < 0.001). Lower PAPP-A MoM level had a significantly higher likelihood of preterm delivery (p < 0.05). When preterm premature rupture of membranes (PPROM) and preterm labor (PTL) were analyzed separately, there was an increasing likelihood of PPROM with decreasing PAPP-A MoM levels (p < 0.05), but not for PTL with intact membranes. CONCLUSION: Low maternal serum PAPP-A levels during the first trimester may reflect a trophoblast invasion defect in the maternal-fetal interface, resulting in subsequent preterm delivery, particularly in those of PPROM. |
| | |
Authors:
|
Bo-Quing She; Su-Chee Chen; Fa-Kung Lee; Mei-Leng Cheong; Ming-Song Tsai |
Related Documents
:
|
16157133 - Periviable birth at 20 to 26 weeks of gestation: proximate causes, previous obstetric h... 16488483 - Simple and highly efficient method for transient in vivo gene transfer to mid-late preg... 16967683 - Pelvic vascular prospects for uterine transplantation. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Taiwanese journal of obstetrics & gynecology Volume: 46 ISSN: 1875-6263 ISO Abbreviation: - Publication Date: 2007 Sep |
Date Detail:
|
Created Date: 2007-10-26 Completed Date: 2007-12-18 Revised Date: 2007-12-28 |
Medline Journal Info:
|
Nlm Unique ID: 101213819 Medline TA: Taiwan J Obstet Gynecol Country: China |
Other Details:
|
Languages: eng Pagination: 242-7 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Case-Control Studies Female Fetal Membranes, Premature Rupture / blood*, etiology Gestational Age Humans Linear Models Pregnancy Pregnancy Trimester, First / blood* Pregnancy-Associated Plasma Protein-A / metabolism* Premature Birth / blood*, etiology Probability |
| Chemical | |
Reg. No./Substance:
|
EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prevalence of gestational diabetes mellitus and pregnancy outcomes in Iranian women.
Next Document: The interns' learning assessment in obstetrics and gynecology department of Zahedan University of Me...