Document Detail

Low maternal serum concentrations of human chorionic gonadotropin as part of the triple test screening: a follow-up study.
MedLine Citation:
PMID:  12916678     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether low maternal serum concentrations of human chorionic gonadotropin (hCG) were associated with poor pregnancy outcome. METHODS: Between 1999 and 2000, 20,880 women underwent triple test screening in our hospital. The levels of hCG were detected by fluorescent immunoassay. Low hCG levels (< or = 0.20 MoM in our center) were considered to be a marker for increased risk for trisomy 18 or adverse pregnancy outcome. Each patient completed a questionnaire regarding fetal karyotype, complications of pregnancy and pregnancy outcome. RESULTS: Low maternal serum concentrations of hCG were detected in 119 pregnancies (0.57%). Of these, 19 (16%) were found to be missed abortions. The distribution of the remaining 100 cases was as follows: 72% had an isolated low hCG level, 24% had a low hCG level and a combination of hCG + alpha-fetoprotein < 0.80 MoM, and 4% had a low hCG level and a combination of hCG + unconjugated estriol < 0.80 MoM. No trisomy 18 or other chromosomal abnormalities were detected in our patient population. However, there were perinatal complications. CONCLUSION: Based on our screened population, a combination of multiple analytes seemed to be a better marker than an isolated finding of low maternal serum concentrations of hCG with regards to abnormal fetal karyotype, specifically trisomy 18, although it did determine a high-risk group in terms of complications of pregnancy.
R Sharony; J Grinshpun-Cohen; K Rabi; A Amiel; M Fejgin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  13     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-08-14     Completed Date:  2003-12-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  300-4     Citation Subset:  IM    
The Genetic Institute, Sapir Medical Center-Meir Hospital, Kfar Saba, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
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MeSH Terms
Chorionic Gonadotropin / blood*
Chromosomes, Human, Pair 18
Cohort Studies
Follow-Up Studies
Pregnancy Outcome*
Retrospective Studies
Reg. No./Substance:
0/Chorionic Gonadotropin

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