| Low maternal serum concentrations of human chorionic gonadotropin as part of the triple test screening: a follow-up study. | |
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MedLine Citation:
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PMID: 12916678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether low maternal serum concentrations of human chorionic gonadotropin (hCG) were associated with poor pregnancy outcome. METHODS: Between 1999 and 2000, 20,880 women underwent triple test screening in our hospital. The levels of hCG were detected by fluorescent immunoassay. Low hCG levels (< or = 0.20 MoM in our center) were considered to be a marker for increased risk for trisomy 18 or adverse pregnancy outcome. Each patient completed a questionnaire regarding fetal karyotype, complications of pregnancy and pregnancy outcome. RESULTS: Low maternal serum concentrations of hCG were detected in 119 pregnancies (0.57%). Of these, 19 (16%) were found to be missed abortions. The distribution of the remaining 100 cases was as follows: 72% had an isolated low hCG level, 24% had a low hCG level and a combination of hCG + alpha-fetoprotein < 0.80 MoM, and 4% had a low hCG level and a combination of hCG + unconjugated estriol < 0.80 MoM. No trisomy 18 or other chromosomal abnormalities were detected in our patient population. However, there were perinatal complications. CONCLUSION: Based on our screened population, a combination of multiple analytes seemed to be a better marker than an isolated finding of low maternal serum concentrations of hCG with regards to abnormal fetal karyotype, specifically trisomy 18, although it did determine a high-risk group in terms of complications of pregnancy. |
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Authors:
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R Sharony; J Grinshpun-Cohen; K Rabi; A Amiel; M Fejgin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 13 ISSN: 1476-7058 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-08-14 Completed Date: 2003-12-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: United States |
Other Details:
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Languages: eng Pagination: 300-4 Citation Subset: IM |
Affiliation:
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The Genetic Institute, Sapir Medical Center-Meir Hospital, Kfar Saba, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chorionic Gonadotropin
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blood* Chromosomes, Human, Pair 18 Cohort Studies Female Follow-Up Studies Humans Male Pregnancy Pregnancy Outcome* Retrospective Studies Trisomy |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin |
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