| Low maternal alcohol consumption during pregnancy and oral clefts in offspring: the Slone Birth Defects Study. | |
| | |
MedLine Citation:
|
PMID: 14565622 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The association between maternal alcohol consumption during pregnancy and oral clefts in offspring remains unclear. We studied this relation in a case-control surveillance study of birth defects. METHODS: From 1983 to 1997, we recruited 5956 study subjects from greater Boston, Philadelphia, Toronto, and parts of Iowa. The cases were liveborn infants with cleft palate alone (CP; n = 205), cleft lip and palate (CLP; n = 383), cleft lip alone (CL; n = 259), or Pierre-Robin sequence (n = 65). The controls (n = 4272) were infants who had no oral clefts but had one or more of the following defects: malformations of the digestive tract, reproductive organs, abdominal wall, and respiratory tract; chromosomal anomalies; inguinal hernia; tumors; and Mendelian inherited disorders. Based on maternal reports of alcohol consumption during the first 4 months of pregnancy, we derived average weekly consumption, average number of drinks per drinking day, and the maximum number of drinks consumed in a given day. The mothers also provided data on potential confounding or modifying variables, such as vitamin supplement use. RESULTS: There was no relation between maternal alcohol consumption during pregnancy and CL or CP. The odds ratios (ORs) for cleft lip with or without palate (CL/P) were 1.0, 1.1, and 0.9 in women who consumed <1.0, 1.0-2.9, and 3.0 + drinks per week, respectively. These findings did not change when we considered possible modifying effects of vitamin supplement use. CONCLUSIONS: Our findings do not support an association between oral clefts and a low level of alcohol consumption. |
| | |
Authors:
|
Katie A Meyer; Martha M Werler; Catherine Hayes; Allen A Mitchell |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Birth defects research. Part A, Clinical and molecular teratology Volume: 67 ISSN: 1542-0752 ISO Abbreviation: Birth Defects Res. Part A Clin. Mol. Teratol. Publication Date: 2003 Jul |
Date Detail:
|
Created Date: 2003-10-20 Completed Date: 2004-03-09 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 101155107 Medline TA: Birth Defects Res A Clin Mol Teratol Country: United States |
Other Details:
|
Languages: eng Pagination: 509-14 Citation Subset: IM |
Affiliation:
|
Department of Applied Medical Sciences, School of Applied Science, Engineering, and Technology, University of Southern Maine, Portland, Maine, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Alcohol Drinking / adverse effects* Case-Control Studies Cleft Lip / chemically induced*, epidemiology Cleft Palate / chemically induced*, epidemiology Dietary Supplements Female Humans Infant, Newborn Odds Ratio Pregnancy Prenatal Exposure Delayed Effects* Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
|
R01 ES10855/ES/NIEHS NIH HHS; R01 HL58763/HL/NHLBI NIH HHS; T32 DE07151/DE/NIDCR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diarrhea: a new risk factor for neural tube defects?
Next Document: Birth defects in the offspring of non-Caucasian, non-Indigenous women in Western Australia.