Document Detail

Low mannose-binding lectin (MBL) levels in neonates with pneumonia and sepsis.
MedLine Citation:
PMID:  17711490     Owner:  NLM     Status:  MEDLINE    
We investigated whether deficiency of mannose-binding lectin (MBL), a component of innate immunity, is associated with neonatal pneumonia and sepsis during the first 72 h, i.e. early onset, and during the first month after birth. In 88 neonatal intensive care patients (71 premature), MBL2 genotype and MBL plasma levels at birth were determined prospectively by Taqman analysis and enzyme-linked immunosorbent assay, respectively. Thirty-five neonates (40%) had low, i.e. </= 0.7 microg/ml, MBL plasma levels at birth. Median (interquartile range) MBL plasma levels in 32 no early-onset sepsis (EOS) cases, 44 possible EOS cases and 11 EOS cases were 1.57 (0.57-2.67) microg/ml, 1.05 (0.41-1.70) microg/ml and 0.20 (0.10-0.77) microg/ml, respectively (P < 0.01). During the first month, 28 neonates (32%) had no infection, 49 (55%) had suspected infection, five (6%) had pneumonia and six (7%) had culture-proven sepsis. Low MBL levels at birth were associated both with an increased risk of developing pneumonia (OR: 12.0; 95% CI: 1.1-126.1; P = 0.04) and culture-proven sepsis (OR: 15.0; 95% CI: 1.5-151.3; P = 0.02). These results were confirmed by genetic analysis of MBL deficiency. Low MBL levels at birth are associated with an increased risk of early-onset sepsis, culture-proven sepsis and pneumonia during the first month of life.
F N J Frakking; N Brouwer; N K A van Eijkelenburg; M P Merkus; T W Kuijpers; M Offringa; K M Dolman
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-17
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  150     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-16     Completed Date:  2007-12-18     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  255-62     Citation Subset:  IM    
Departments of Clinical Immunology, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands.
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MeSH Terms
Delivery, Obstetric / methods
Disease Susceptibility
Gestational Age
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / immunology
Intensive Care
Mannose-Binding Lectin / blood,  deficiency*,  genetics
Pneumonia, Bacterial / immunology*
Prospective Studies
Sepsis / immunology*
Reg. No./Substance:
0/MBL2 protein, human; 0/Mannose-Binding Lectin

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