Document Detail


Low major histocompatibility complex diversity in the Tasmanian devil predates European settlement and may explain susceptibility to disease epidemics.
MedLine Citation:
PMID:  23221872     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Tasmanian devil (Sarcophilus harrisii) is at risk of extinction owing to the emergence of a contagious cancer known as devil facial tumour disease (DFTD). The emergence and spread of DFTD has been linked to low genetic diversity in the major histocompatibility complex (MHC). We examined MHC diversity in historical and ancient devils to determine whether loss of diversity is recent or predates European settlement in Australia. Our results reveal no additional diversity in historical Tasmanian samples. Mainland devils had common modern variants plus six new variants that are highly similar to existing alleles. We conclude that low MHC diversity has been a feature of devil populations since at least the Mid-Holocene and could explain their tumultuous history of population crashes.
Authors:
Katrina Morris; Jeremy J Austin; Katherine Belov
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-12-05
Journal Detail:
Title:  Biology letters     Volume:  9     ISSN:  1744-957X     ISO Abbreviation:  Biol. Lett.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2012-12-10     Completed Date:  2013-05-09     Revised Date:  2014-02-25    
Medline Journal Info:
Nlm Unique ID:  101247722     Medline TA:  Biol Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  20120900     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alleles
Amino Acid Sequence
Animals
Australia
Cloning, Molecular
Endangered Species
Facial Neoplasms / epidemiology,  genetics,  immunology,  veterinary*
Fossils
Genetic Predisposition to Disease / epidemiology
Genetic Variation*
Genotype
Major Histocompatibility Complex*
Marsupialia / genetics*
Phylogeny
Polymerase Chain Reaction / veterinary
Sequence Alignment / veterinary
Sequence Analysis, DNA / veterinary
Time Factors
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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