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Low-loading asymmetric organocatalysis.
MedLine Citation:
PMID:  22167174     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Asymmetric organocatalysis is now recognized as the third pillar of asymmetric synthesis. Recent years have witnessed increasing interest towards the use of highly active and stereoselective organocatalysts. This critical review documents the advances in the development of chiral organocatalysts which are systematically used in ≤3 mol% loading in all the sub-areas of the field, namely aminocatalysis, Brønsted acids and bases, Lewis acids and bases, hydrogen bond-mediated catalysis, phase transfer and N-heterocyclic carbene catalyses (194 references).
Authors:
Francesco Giacalone; Michelangelo Gruttadauria; Paola Agrigento; Renato Noto
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-14
Journal Detail:
Title:  Chemical Society reviews     Volume:  -     ISSN:  1460-4744     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0335405     Medline TA:  Chem Soc Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari (STEMBIO) Sez. Chimica Organica "E. Paternò", Università di Palermo, Viale delle Scienze, Ed. 17, 90128, Palermo, Italy. michelangelo.gruttadauria@unipa.it.
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