Document Detail


Low load inspiratory muscle training increases diaphragmatic fiber dimensions in rats.
MedLine Citation:
PMID:  9517599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of 8 wk of inspiratory resistive loading (30 min/d, 3 x/wk) on diaphragm mass, contractile properties, fatigue, and fiber dimensions were studied in 10 male Wistar rats. They were conditioned to breathe through a Hans-Rudolph device. Half of them had to overcome a moderate inspiratory resistance (MR; n = 5), whereas the others only had to overcome the small resistance (SR; n = 5) of the inspiratory valve of the device. Results were compared with control rats (C; n = 5) moving and breathing freely. At the end of training, animals submitted to MR and SR generated mean inspiratory pressures of -2.5 +/- 1.1 and -0.2 +/- 0.05 cm H2O, respectively. TI/Ttot was 0.60 +/- 0.06 and 0.57 +/- 0.05, respectively. Body and diaphragm weight were unaffected by loading. Little or no change in in vitro diaphragmatic twitch kinetics, force generation, and fatigability was found between the three groups. Nevertheless, cross-sectional area of all fiber types increased in the two loaded groups compared with control animals. This increase reached statistical significance for type I fibers in the MR group (846 +/- 74 microm2) compared with the C and SR groups (589 +/- 32 and 683 +/- 96 microm2, respectively, p < 0.05). For IIa fibers both training groups were significantly different from the control group (SR: 768 +/- 99 and MR: 790 +/- 108 versus C: 592 +/- 37 microm2, p < 0.05). A hypertrophy of type IIx/b fibers was seen in MR compared with control animals (C: 1,555 +/- 136, SR: 1,845 +/- 338, MR: 2,053 +/- 326 microm2, p < 0.05). No differences were present in fiber type proportions between the three groups. We conclude that in our training setup, 8 wk of intermittent long-term inspiratory loading stressed the diaphragm already with a small resistance resulting in hypertrophy of predominantly type IIa fibers. A higher resistance resulted in hypertrophy of all fiber types.
Authors:
H Rollier; A Bisschop; G Gayan-Ramirez; R Gosselink; M Decramer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  157     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-04-07     Completed Date:  1998-04-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  833-9     Citation Subset:  AIM; IM; S    
Affiliation:
Respiratory Muscle Research Unit, Laboratory of Pneumology, Katholieke Universiteit Leuven, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight
Breathing Exercises
Diaphragm / physiology,  ultrastructure*
Hypertrophy
Inhalation / physiology*
Male
Muscle Contraction / physiology
Muscle Fatigue / physiology
Muscle Fibers, Fast-Twitch / physiology,  ultrastructure
Muscle Fibers, Skeletal / physiology,  ultrastructure*
Muscle Fibers, Slow-Twitch / physiology,  ultrastructure
Organ Size
Pressure
Rats
Rats, Wistar
Respiration / physiology
Respiratory Mechanics / physiology
Stress, Mechanical

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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