Document Detail

Low levels of serum cholesterol and systolic blood pressure in Japanese with the apolipoprotein E3/2 genotype.
MedLine Citation:
PMID:  10437639     Owner:  NLM     Status:  MEDLINE    
Apolipoprotein E (apoE) plays an important role in lipoprotein and cholesterol metabolism. An association between serum cholesterol and blood pressure has been suggested by epidemiological and experimental studies. But it is still not clear whether the apoE polymorphism plays a role in regulating blood pressure. The present study was undertaken to determine the association among apoE genotype, serum cholesterol and blood pressure in 303 healthy Japanese workers. Amplified fragments of DNA by the polymerase chain reaction were digested with HhaI and analyzed by 3% agarose-gel electrophoresis. Individuals with the apoE3/2 genotype had significantly lower levels of total cholesterol and systolic blood pressure than either the apoE3/3 individuals or the apoE3/4 + 4/4 individuals (P <0.05). The hypothesis that apoE indirectly influences systolic blood pressure through total serum cholesterol was supported by a covariance analysis of linear structural equations.
K Shiwaku; T Q Gao; N Hojo; T Fukushima; Y Yamane
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  284     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-08-31     Completed Date:  1999-08-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  15-23     Citation Subset:  IM    
Department of Environmental Medicine, Shimane Medical University, Izumo City, Japan.
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MeSH Terms
Apolipoprotein E2
Apolipoprotein E3
Apolipoproteins E / genetics*
Base Sequence
Blood Pressure / genetics*
Cholesterol / blood*
Confounding Factors (Epidemiology)
DNA Primers
Gene Frequency
Middle Aged
Reg. No./Substance:
0/Apolipoprotein E2; 0/Apolipoprotein E3; 0/Apolipoproteins E; 0/DNA Primers; 57-88-5/Cholesterol

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