Document Detail

Low levels of serum apolipoprotein A I and A II in senile dementia.
MedLine Citation:
PMID:  7891423     Owner:  NLM     Status:  MEDLINE    
We studied the serum lipoprotein and apolipoprotein profiles in 44 patients with sporadic late-onset Alzheimer's dementia and 43 patients with vascular dementia. The levels of high-density lipoprotein (HDL) cholesterol were lower in both patient groups than in a control group. Apolipoprotein A I and A II levels have decreased in both the patient groups, especially in the vascular dementia group. The HDL-cholesterol levels correlated positively with the level of apolipoprotein A I, but not with the level of apolipoprotein A II. The ratios of apolipoprotein A I/A II have increased in both the patient groups. The apolipoprotein A II levels have disproportionally decreased in the patient groups. The serum apolipoprotein A II may involve the pathological process in the patients with senile dementia.
M Kuriyama; K Takahashi; T Yamano; Y Hokezu; S Togo; M Osame; T Igakura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Japanese journal of psychiatry and neurology     Volume:  48     ISSN:  0912-2036     ISO Abbreviation:  Jpn. J. Psychiatry Neurol.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-04-20     Completed Date:  1995-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610886     Medline TA:  Jpn J Psychiatry Neurol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  589-93     Citation Subset:  IM    
Third Department of Internal Medicine, Kagoshima University School of Medicine, Kagoshima, Japan.
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MeSH Terms
Alzheimer Disease / blood
Apolipoproteins A / blood*
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Dementia / blood*
Lipids / blood
Lipoproteins / blood
Risk Factors
Triglycerides / blood
Reg. No./Substance:
0/Apolipoproteins A; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids; 0/Lipoproteins; 0/Triglycerides

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