Document Detail

Low levels of procalcitonin during episodes of necrotizing enterocolitis.
MedLine Citation:
PMID:  17393328     Owner:  NLM     Status:  MEDLINE    
The pathogenesis of necrotizing enterocolitis (NEC) remains poorly understood. We aimed to assess the extent of bacterial infection in the pathogenesis of NEC using serial procalcitonin measurements. Blood samples were drawn during the first 4 days following every clinical event requiring a workup for presumed NEC. Eight episodes were confirmed as NEC, 7 of which showed procalcitonin levels <1 ng/ml at presentation and <1.3 ng/ml thereafter, comparable to 24 healthy controls. The one infant with elevated procalcitonin had bacteremia in addition to NEC. Procalcitonin levels of 24 matched septic infants were higher than those of NEC infants, peaking at 4.1 ng/ml. We conclude that low procalcitonin values are the rule during episodes of NEC and provide further evidence that overactive local immune response, and not active infection, is primarily responsible for the mucosal damage in NEC.
Dan Turner; Cathy Hammerman; Bernard Rudensky; Yechiel Schlesinger; Eytan Wine; Aleixo Muise; Michael S Schimmel
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Publication Detail:
Type:  Journal Article     Date:  2007-03-28
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  52     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-02     Completed Date:  2007-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2972-6     Citation Subset:  AIM; IM    
Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel.
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MeSH Terms
Biological Markers / blood
Calcitonin / blood*
Enterocolitis, Necrotizing / blood*
Follow-Up Studies
Infant, Newborn
Infant, Premature
Prospective Studies
Protein Precursors / blood*
Severity of Illness Index
Reg. No./Substance:
0/Biological Markers; 0/Glycoproteins; 0/Protein Precursors; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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