| Low levels of linoleic acid in plasma total lipids of HIV-1 seropositive children. | |
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MedLine Citation:
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PMID: 9477386 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the plasma fatty acid status of a group of well-nourished children with the human immunodeficiency virus type-1 (HIV-1) and how this relates to the blood total CD4+ lymphocyte count. SUBJECTS: Fourteen HIV-1 seropositive children at various stages of disease and with adequate growth indices were assessed and compared to a control group of 30 healthy children. RESULTS: The concentrations (mg/dL) of plasma total fatty acids were not different between the two groups. HIV-1 seropositive children presented lower levels of 18-C essential polyunsaturated fatty acids (PUFA: linoleic acid, LA, and alpha-linolenic acid) and higher levels of their 20-C long-chain derivatives (di-homo-gamma-linolenic acid, arachidonic acid, AA, and eicosapentaenoic acid) and docosahexaenoic acid in their plasma total lipids. The lowest plasma LA levels were observed in the subgroup of patients with more advanced stages of disease. In bivariate analyses the plasma LA levels related positively (Spearman r = 0.50, p = 0.06), while the LA/AA ratio related negatively (Spearman r = -0.51, p = 0.06), to the total CD4+ count. CONCLUSIONS: Childhood HIV-1 infection is associated with changes in plasma fatty acid profile suggestive of an increased PUFA turnover. Decreased levels of LA (together with higher plasma AA levels) appear to be associated with more advanced clinical and biochemical stages of disease. |
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Authors:
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C Agostoni; G V Zuccotti; E Riva; S Decarlis; L Bernardo; M G Bruzzese; M Giovannini |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American College of Nutrition Volume: 17 ISSN: 0731-5724 ISO Abbreviation: J Am Coll Nutr Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-04-03 Completed Date: 1998-04-03 Revised Date: 2008-06-23 |
Medline Journal Info:
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Nlm Unique ID: 8215879 Medline TA: J Am Coll Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 25-9 Citation Subset: IM; X |
Affiliation:
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Department of Pediatrics, University of Milan Medical School, San Paolo Hospital, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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8,11,14-Eicosatrienoic Acid Anthropometry CD4 Lymphocyte Count Child Child, Preschool Dietary Fats / administration & dosage Dietary Proteins / administration & dosage Docosahexaenoic Acids / blood Energy Intake Fatty Acids, Unsaturated / blood Female HIV Seropositivity / blood* Humans Infant Linoleic Acid / blood* Lipids / blood* Male Micronutrients |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Dietary Proteins; 0/Fatty Acids, Unsaturated; 0/Lipids; 0/Micronutrients; 2197-37-7/Linoleic Acid; 25167-62-8/Docosahexaenoic Acids; 7324-41-6/8,11,14-Eicosatrienoic Acid |
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