Document Detail

Low levels of heat shock proteins-60 and -65 autoantibodies in Sjögren's syndrome.
MedLine Citation:
PMID:  16382698     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Heat shock proteins are highly conserved immunodominant antigens found in various species. Humoral immune responses to mycobacterial HSP65 and human HSP60 have been established in a number of human autoimmune diseases. OBJECTIVE: To assess the prevalence of antibodies to HSP60 kDa and HSP65 kDa in patients with Sjögren's syndrome as compared to normal subjects. METHODS: Thirty-seven patients with SS were compared with normal controls. The antibodies against human HSP60 were measured by the Anti-Human (IgG/IgM) HSP60 ELISA kit. IgGs and IgMs to mycobacterial HSP65 were determined using an enzyme-linked immunosorbent assay with mycobacterial recombinant HSP65 antigens. RESULTS: The levels of both anti-HSP60 and -HSP65 were lower in patients compared with controls. IgG autoantibodies to HSP60 were significantly different between groups: 162 +/- 55.1 ng/ml in controls versus 112.3 +/- 30.6 ng/ml in SS patients (P < 0.001). The levels among controls of anti-HSP65 IgM isotype were also significantly higher than among the SS patients: 111.6 +/- 33.4 U/ml versus 96.1 +/- 8.9 U/ml (P= 0.01). CONCLUSIONS: The results of the present study show that the levels of different isotypes of anti- HSP60 and HSP65 antibodies were lower in patients with SS than in normal subjects. Additional studies in larger patient populations are required to evaluate the prevalence of these autoantibodies in SS patients.
Ora Shovman; Yaniv Sherer; Boris Gilbourd; Roberto Gerli; Elena Bartoloni Bocci; Francesco delle Monache; Filippo Luccioli; Yehuda Shoenfeld
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Israel Medical Association journal : IMAJ     Volume:  7     ISSN:  1565-1088     ISO Abbreviation:  Isr. Med. Assoc. J.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-30     Completed Date:  2006-01-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  100930740     Medline TA:  Isr Med Assoc J     Country:  Israel    
Other Details:
Languages:  eng     Pagination:  778-80     Citation Subset:  IM    
Department of Medicine B and Center of Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel.
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MeSH Terms
Autoantibodies / isolation & purification*
Bacterial Proteins / blood,  immunology*
Case-Control Studies
Chaperonin 60 / blood,  immunology*
Chaperonins / blood,  immunology*
Enzyme-Linked Immunosorbent Assay
Immunoglobulin G / immunology*
Sjogren's Syndrome / blood,  immunology*
Reg. No./Substance:
0/Autoantibodies; 0/Bacterial Proteins; 0/Chaperonin 60; 0/Immunoglobulin G; 0/heat-shock protein 65, Mycobacterium; EC 3.6.1.-/Chaperonins

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