| Low-level subchronic arsenic exposure from prenatal developmental stages to adult life results in an impaired glucose homeostasis. | |
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MedLine Citation:
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PMID: 22068553 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We evaluated how low-level (3 ppm) subchronic inorganic arsenic (iAs) exposure from prenatal developmental stages until adult life affects glucose homeostasis. Biochemical parameters of glucose and lipid metabolism, pancreatic insulin and glycosylated haemoglobin were determined in 4-month-old female offspring of adult Wistar rats. Pancreatic histology was also performed. Statistical comparisons between control and iAs-treated groups were performed by unpaired two-tailed Student's t-test. Statistical significance was set at p<0.05. We found that iAs treatment resulted in an impaired glucose tolerance test, suggestive of impaired glucose metabolism. This group was found to have hyperglycaemia and high levels of HOMA-IR, glycosylated haemoglobin, cholesterol and pancreatic insulin compared to control rats. However, plasma insulin, triglycerides and high-density lipoprotein cholesterol were not different from control rats. Moreover, β-cell damage found in iAs-treated rats consisted of cells with a nucleus with dense chromatin and predominance of eosinophilic cytoplasm, as well as changes in the pancreatic vasculature. The current study provided evidence that subchronic iAs exposure at 3 ppm from prenatal developmental stages to adult life resulted in damage to pancreatic β cells, affected insulin secretion and demonstrated altered glucose homeostasis, thus supporting a causal association between iAs exposure and diabetes. |
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Authors:
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M E Dávila-Esqueda; J M Morales; M E Jiménez-Capdeville; E De la Cruz; R Falcón-Escobedo; E Chi-Ahumada; S Martin-Pérez |
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Publication Detail:
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Type: Journal Article Date: 2011-11-08 |
Journal Detail:
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Title: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Volume: 119 ISSN: 1439-3646 ISO Abbreviation: Exp. Clin. Endocrinol. Diabetes Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505926 Medline TA: Exp Clin Endocrinol Diabetes Country: Germany |
Other Details:
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Languages: eng Pagination: 613-7 Citation Subset: IM |
Copyright Information:
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© J. A. Barth Verlag in George Thieme Verlag KG Stuttgart · New York. |
Affiliation:
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Departamento de Farmacología. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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