| Low level nitrate or nitroethane preconditioning enhances the bactericidal effect of suboptimal experimental chlorate treatment against Escherichia coli and Salmonella Typhimurium but not Campylobacter in swine. | |
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MedLine Citation:
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PMID: 17199529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An experimental chlorate product that targets the respiratory nitrate reductase enzyme of bacteria such as Salmonella and Escherichia coli has shown promising results in reducing concentrations of these bacteria in the gut of food animals. Because expression of the target enzyme is induced by nitrate, we administered short-duration, low level nitrate or nitroethane preconditioning treatments to finishing swine to see if these would enhance the ability of an experimental chlorate product to kill these bacteria. Results from these studies showed that preconditioning the gut microflora of swine with low levels of nitrate or nitrocompounds enhanced (more than tenfold) the ability of the chlorate product to kill Salmonella and E. coli, but not Campylobacter. Further studies are needed before these compounds can be fed as feed additives to animals, although it is likely that nitrate preconditioning may be more near to market than the nitrocompounds, which may require more comprehensive review by regulatory authorities. |
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Authors:
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Robin C Anderson; Yong Soo Jung; Kenneth J Genovese; Jackson L McReynolds; Todd R Callaway; Thomas S Edrington; Roger B Harvey; David J Nisbet |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Foodborne pathogens and disease Volume: 3 ISSN: 1535-3141 ISO Abbreviation: Foodborne Pathog. Dis. Publication Date: 2006 |
Date Detail:
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Created Date: 2007-01-03 Completed Date: 2007-02-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101120121 Medline TA: Foodborne Pathog Dis Country: United States |
Other Details:
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Languages: eng Pagination: 461-5 Citation Subset: IM |
Affiliation:
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Food and Feed Safety Research Unit, Southern Plains Agricultural Research Center, USDA-ARS, College Station, Texas 77845, USA. anderson@ffsru.tamu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed Animals Anti-Bacterial Agents / pharmacology* Campylobacter / drug effects, enzymology, growth & development Chlorates / pharmacology* Escherichia coli / drug effects*, enzymology, growth & development Ethane / administration & dosage, analogs & derivatives, pharmacology Food Microbiology Humans Nitrate Reductase / metabolism* Nitrates / administration & dosage, pharmacology Nitrogen Compounds / administration & dosage*, pharmacology Nitroparaffins / administration & dosage, pharmacology Random Allocation Salmonella typhimurium / drug effects*, enzymology, growth & development Swine Swine Diseases / prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Chlorates; 0/Nitrates; 0/Nitrogen Compounds; 0/Nitroparaffins; 74-84-0/Ethane; 79-24-3/nitroethane; EC 1.7.99.4/Nitrate Reductase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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