Document Detail

Low level nitrate or nitroethane preconditioning enhances the bactericidal effect of suboptimal experimental chlorate treatment against Escherichia coli and Salmonella Typhimurium but not Campylobacter in swine.
MedLine Citation:
PMID:  17199529     Owner:  NLM     Status:  MEDLINE    
An experimental chlorate product that targets the respiratory nitrate reductase enzyme of bacteria such as Salmonella and Escherichia coli has shown promising results in reducing concentrations of these bacteria in the gut of food animals. Because expression of the target enzyme is induced by nitrate, we administered short-duration, low level nitrate or nitroethane preconditioning treatments to finishing swine to see if these would enhance the ability of an experimental chlorate product to kill these bacteria. Results from these studies showed that preconditioning the gut microflora of swine with low levels of nitrate or nitrocompounds enhanced (more than tenfold) the ability of the chlorate product to kill Salmonella and E. coli, but not Campylobacter. Further studies are needed before these compounds can be fed as feed additives to animals, although it is likely that nitrate preconditioning may be more near to market than the nitrocompounds, which may require more comprehensive review by regulatory authorities.
Robin C Anderson; Yong Soo Jung; Kenneth J Genovese; Jackson L McReynolds; Todd R Callaway; Thomas S Edrington; Roger B Harvey; David J Nisbet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Foodborne pathogens and disease     Volume:  3     ISSN:  1535-3141     ISO Abbreviation:  Foodborne Pathog. Dis.     Publication Date:  2006  
Date Detail:
Created Date:  2007-01-03     Completed Date:  2007-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120121     Medline TA:  Foodborne Pathog Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  461-5     Citation Subset:  IM    
Food and Feed Safety Research Unit, Southern Plains Agricultural Research Center, USDA-ARS, College Station, Texas 77845, USA.
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MeSH Terms
Animal Feed
Anti-Bacterial Agents / pharmacology*
Campylobacter / drug effects,  enzymology,  growth & development
Chlorates / pharmacology*
Escherichia coli / drug effects*,  enzymology,  growth & development
Ethane / administration & dosage,  analogs & derivatives,  pharmacology
Food Microbiology
Nitrate Reductase / metabolism*
Nitrates / administration & dosage,  pharmacology
Nitrogen Compounds / administration & dosage*,  pharmacology
Nitroparaffins / administration & dosage,  pharmacology
Random Allocation
Salmonella typhimurium / drug effects*,  enzymology,  growth & development
Swine Diseases / prevention & control*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Chlorates; 0/Nitrates; 0/Nitrogen Compounds; 0/Nitroparaffins; 74-84-0/Ethane; 79-24-3/nitroethane; EC Reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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