| Low-level laser treatment with near-infrared light increases venous nitric oxide levels acutely: a single-blind, randomized clinical trial of efficacy. | |
| | |
MedLine Citation:
|
PMID: 23334615 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: The use of near-infrared light in the form of low-level laser therapy (LLLT) has become more popular in the treatment of a variety of conditions where increased peripheral blood flow is desired. The hypothesis behind its working mechanism is its purported ability to generate nitric oxide (NO) in the treated area. We tested the hypothesis that the efficacy of near-infrared light lies in its ability to generate NO at the treatment site. DESIGN: We conducted a single-blind, placebo-controlled, randomized clinical trial to measure NO, by its metabolites nitrite and nitrate, in venous blood draining from tissue receiving LLLT. Fifteen healthy subjects received LLLT to the forearm, and blood samples were taken immediately before treatment; at 1, 5, 15, and 30 mins; as well as 15 mins after the treatment to check for NO content. RESULTS: We found a significant treatment effect (F = 15.75, P = 0.003). A post hoc test showed that minutes 1, 5, and 15 were different compared with the baseline measures (P's < 0.05). The area under the treatment curve was significantly larger than the area under the sham treatment curve (t = 2.26, P = 0.037). A limitation of this study was that the data were collected from healthy subjects. CONCLUSIONS: LLLT increased NO levels in venous blood draining from the treatment site in healthy subjects. The peak increase in NO occurred 5 mins into the treatment, after which it slowly waned. Further research is necessary to assess NO increases with LLLT in patients with pathologies. |
| | |
Authors:
|
Ulrike H Mitchell; Gary L Mack |
Related Documents
:
|
10493275 - Adefovir dipivoxil. 12942405 - How does expert advice impact genotypic resistance testing in clinical practice? 20368815 - Intermittent preventive treatment in infants for the prevention of malaria in rural wes... 22945215 - The brain derived neurotrophic factor and influences of stress in depression. 7924325 - Studies on a vaginal ring releasing levonorgestrel at an initial rate of 27 micrograms/... 11796095 - Relationships between event-related potentials (p300) and activities of daily living in... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of physical medicine & rehabilitation / Association of Academic Physiatrists Volume: 92 ISSN: 1537-7385 ISO Abbreviation: Am J Phys Med Rehabil Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-01-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8803677 Medline TA: Am J Phys Med Rehabil Country: United States |
Other Details:
|
Languages: eng Pagination: 151-6 Citation Subset: AIM; IM |
Affiliation:
|
From the Department of Exercise Sciences, Brigham Young University, Provo, Utah (UHM, GLM). |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical significance of the double-peak sensory response in nerve conduction study of normal and di...
Next Document: Amputee care education in physical medicine and rehabilitation residency programs.