Document Detail

Low level IGF-1 and common variable immune deficiency: an unusual combination.
MedLine Citation:
PMID:  18931397     Owner:  NLM     Status:  MEDLINE    
A relation between growth hormone (GH) deficiency and immunoglobulin deficiency has been suggested previously in a few cases. We describe a patient with an insulin-like growth factor 1 (IGF-1) deficiency and common variable immune deficiency and briefly review earlier publications on the possible interaction between IGF-1 and the immune system. IGF-1 is the downstream mediator of GH. In this patient, GH and IGF-1 levels were both low. The GH response to a GH-releasing hormone test was normal whereas no subsequent IGF-1 response was seen. In our cohort of 14 patients with hypogammaglobulinaemia, two turned out to have slightly decreased IGF-1 serum levels and one patient with a thymoma had an increased IGF-1 level. Even though IGF-1 may be connected to B lymphocyte differentiation, in this patient we hypothesise there is a common impairment in the IGF-1 and IgG pathways.
K van Bilsen; G J Driessen; R A de Paus; E van de Vosse; K van Lom; M C van Zelm; K H Lam; N G Hartwig; G S Baarsma; M van de Burg; P M van Hagen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Netherlands journal of medicine     Volume:  66     ISSN:  0300-2977     ISO Abbreviation:  Neth J Med     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2009-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0356133     Medline TA:  Neth J Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  368-72     Citation Subset:  IM    
Erasmus Medical School, Rotterdam, the Netherlands.
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MeSH Terms
Antibodies, Anti-Idiotypic / blood,  immunology
Biological Markers / blood
Common Variable Immunodeficiency / blood*,  immunology
Follow-Up Studies
Immunoglobulin A / blood,  immunology
Immunoglobulin G / blood,  immunology
Insulin-Like Growth Factor I / deficiency*
Time Factors
Reg. No./Substance:
0/Antibodies, Anti-Idiotypic; 0/Biological Markers; 0/Immunoglobulin A; 0/Immunoglobulin G; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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