| Low level IGF-1 and common variable immune deficiency: an unusual combination. | |
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MedLine Citation:
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PMID: 18931397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A relation between growth hormone (GH) deficiency and immunoglobulin deficiency has been suggested previously in a few cases. We describe a patient with an insulin-like growth factor 1 (IGF-1) deficiency and common variable immune deficiency and briefly review earlier publications on the possible interaction between IGF-1 and the immune system. IGF-1 is the downstream mediator of GH. In this patient, GH and IGF-1 levels were both low. The GH response to a GH-releasing hormone test was normal whereas no subsequent IGF-1 response was seen. In our cohort of 14 patients with hypogammaglobulinaemia, two turned out to have slightly decreased IGF-1 serum levels and one patient with a thymoma had an increased IGF-1 level. Even though IGF-1 may be connected to B lymphocyte differentiation, in this patient we hypothesise there is a common impairment in the IGF-1 and IgG pathways. |
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Authors:
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K van Bilsen; G J Driessen; R A de Paus; E van de Vosse; K van Lom; M C van Zelm; K H Lam; N G Hartwig; G S Baarsma; M van de Burg; P M van Hagen |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Netherlands journal of medicine Volume: 66 ISSN: 0300-2977 ISO Abbreviation: Neth J Med Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-20 Completed Date: 2009-02-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0356133 Medline TA: Neth J Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 368-72 Citation Subset: IM |
Affiliation:
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Erasmus Medical School, Rotterdam, the Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antibodies, Anti-Idiotypic / blood, immunology Biological Markers / blood Common Variable Immunodeficiency / blood*, immunology Follow-Up Studies Humans Immunoglobulin A / blood, immunology Immunoglobulin G / blood, immunology Insulin-Like Growth Factor I / deficiency* Male Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anti-Idiotypic; 0/Biological Markers; 0/Immunoglobulin A; 0/Immunoglobulin G; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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