| Low ionic strength promotes association of circulating modified LDL in human blood. | |
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MedLine Citation:
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PMID: 15665915 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The resistance to association of circulating multiply-modified low-density lipoproteins (LDL) isolated from human blood and characterized by a decreased content of sialic acids in comparison with native LDL was studied by analysing light transmission fluctuations. LDL association was stimulated by decreasing environmental ionic strength. It is established that circulating modified LDL are less resistant to association than native LDL. Association of LDL in a medium with low ionic strength was irreversible. Probably, increased capacity to irreversible association determines the atherogenic properties of circulating modified LDL subfraction. |
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Authors:
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O M Panasenko; I V Suprun; A A Mel'nichenko; I A Sobenin; A N Orekhov |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bulletin of experimental biology and medicine Volume: 138 ISSN: 0007-4888 ISO Abbreviation: Bull. Exp. Biol. Med. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2005-01-24 Completed Date: 2005-09-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372557 Medline TA: Bull Exp Biol Med Country: United States |
Other Details:
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Languages: eng Pagination: 248-50 Citation Subset: IM |
Affiliation:
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Laboratory of Atherogenic Mechanisms, Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Ministry of Health, Moscow, Russia. oleg-panasenko@newmail.ru |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arteriosclerosis
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metabolism Humans Lipoproteins, LDL / blood*, chemistry*, metabolism Osmolar Concentration Sialic Acids / analysis |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins, LDL; 0/Sialic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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