| Low intestinal glutamine level and low glutaminase activity in Crohn's disease: a rational for glutamine supplementation? | |
| | |
MedLine Citation:
|
PMID: 17078002 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Intestinal glutamine utilization is integral to mucosal regeneration. We analyzed the systemic and intestinal glutamine status in Crohn's disease (CD) and evaluated the therapeutic effect of glutamine supplementation in an animal model of ileitis. In CD, glutamine concentrations were decreased systemically and in noninflamed and inflamed ileal/colonic mucosa. Mucosal glutaminase activities were depressed in the ileum independent of inflammation but were not different from controls in the colon. In experimental ileitis, oral glutamine feeding prevented macroscopic inflammation, enhanced ileal and colonic glutaminase activities above controls, and normalized the intestinal glutathione redox status. However, glutamine supplementation enhanced myeloperoxidase activity along the gastrointestinal tract and potentiated lipid peroxidation in the colon. In conclusion, glutamine metabolism is impaired in CD. In experimental ileitis, glutamine supplementation prevents inflammatory tissue damage. In the colon, however, which does not use glutamine as its principal energy source, immune enhancement of inflammatory cells by glutamine increases oxidative tissue injury. |
| | |
Authors:
|
Bernd Sido; Cornelia Seel; Achim Hochlehnert; Raoul Breitkreutz; Wulf Dröge |
Publication Detail:
|
Type: Evaluation Studies; Journal Article Date: 2006-11-01 |
Journal Detail:
|
Title: Digestive diseases and sciences Volume: 51 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2006 Dec |
Date Detail:
|
Created Date: 2007-01-01 Completed Date: 2007-02-09 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 2170-9 Citation Subset: AIM; IM |
Affiliation:
|
Department of Surgery, Ruprecht-Karls University, Heidelberg, Germany. bernd_sido@med.uni-heidelberg.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Animals Case-Control Studies Colon / metabolism*, pathology Crohn Disease / diet therapy*, metabolism*, pathology Dietary Supplements Disease Models, Animal Enteral Nutrition Female Glutaminase / metabolism* Glutamine / administration & dosage, metabolism*, therapeutic use* Glutathione / metabolism Humans Ileitis / chemically induced, diet therapy Ileum / metabolism*, pathology Indomethacin Intestinal Mucosa / metabolism, pathology Lipid Peroxidation Male Middle Aged Rats Rats, Sprague-Dawley Rectus Abdominis / metabolism, pathology |
| Chemical | |
Reg. No./Substance:
|
53-86-1/Indomethacin; 56-85-9/Glutamine; 70-18-8/Glutathione; EC 3.5.1.2/Glutaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of a specific cyclooxygenase-gene polymorphism (A-842G/C50T) on the occurrence of peptic ulce...
Next Document: Involvement of cyclooxygenase-2--prostaglandin E2 pathway in interleukin-8 production in gastric can...