Document Detail


Low-intensity treadmill exercise-related changes in the rat stellate ganglion neurons.
MedLine Citation:
PMID:  19115406     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stellate ganglion (SG) represents the main sympathetic input to the heart. This study aimed at investigating physical exercise-related changes in the quantitative aspects of SG neurons in treadmill-exercised Wistar rats. By applying state-of-the-art design-based stereology, the SG volume, total number of SG neurons, mean perikaryal volume of SG neurons, and the total volume of neurons in the whole SG have been examined. Arterial pressure and heart rate were also measured at the end of the exercise period. The present study showed that a low-intensity exercise training program caused a 12% decrease in the heart rate of trained rats. In contrast, there were no effects on systolic pressure, diastolic pressure, or mean arterial pressure. As to quantitative changes related to physical exercise, the main findings were a 21% increase in the fractional volume occupied by neurons in the SG, and an 83% increase in the mean perikaryal volume of SG neurons in treadmill-trained rats, which shows a remarkable neuron hypertrophy. It seems reasonable to infer that neuron hypertrophy may have been the result of a functional overload imposed on the SG neurons by initial posttraining sympathetic activation. From the novel stereological data we provide, further investigations are needed to shed light on the mechanistic aspect of neuron hypertrophy: what role does neuron hypertrophy play? Could neuron hypertrophy be assigned to the functional overload induced by physical exercise?
Authors:
Renato Albuquerque de Oliveira Cavalcanti; Demilto Yamaguchi da Pureza; Mariana Pereira de Melo; Romeu Rodrigues de Souza; Cássia T Bergamaschi; Sandra Lia do Amaral; Helen Tang; Andrzej Loesch; Antonio Augusto Coppi Maciel Ribeiro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroscience research     Volume:  87     ISSN:  1097-4547     ISO Abbreviation:  J. Neurosci. Res.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-03-17     Completed Date:  2009-05-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600111     Medline TA:  J Neurosci Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1334-42     Citation Subset:  IM    
Affiliation:
Laboratory of Stochastic Stereology and Chemical Anatomy, Department of Surgery, College of Veterinary Medicine, University of São Paulo, São Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Blood Pressure
Cell Count
Heart Rate
Hypertrophy
Male
Neurons / cytology,  physiology*
Physical Conditioning, Animal*
Rats
Rats, Wistar
Stellate Ganglion / anatomy & histology,  cytology*,  physiology

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