Document Detail

Low-intensity red laser on the prevention and treatment of induced-oral mucositis in hamsters.
MedLine Citation:
PMID:  18976931     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to investigate the effects of laser phototherapy as preventive and therapeutic regime on induced-oral mucositis in hamsters. DESIGN: The animals were divided into four groups: preventive cryotherapy, preventive laser, therapeutic laser and therapeutic control group. Mucositis was induced in hamsters by intraperitoneal injection of 5-fluorouracil (5-FU) and superficial scratching. All preventive treatment was performed on the right cheek pouch mucosa. The left pouch mucosa was used for a spontaneous development of mucositis and did not receive any preventive therapy. Laser parameters were: lambda=660nm, P= 30mW, D=1.2J/cm(2), Deltat=40s, spot size 3mm(2), I=1W/cm(2). Cryotherapy was done positioning ice packs in the hamster mucosa 5min before 5-FU infusion and 10min afterward. To study the healing of mucositis, the left pouch mucosa of each of the hamsters in the TLG received laser irradiation on the injured area. Irradiation parameters were kept the same as abovementioned. The control hamsters in the TCG did not receive any treatment. The mucositis degree and the animal's body mass were evaluated. An assessment of blood vessels was made based on immunohistochemical staining. RESULTS: The CG animals lost 15.16% of theirs initial body mass while the LG animals lost 8.97% during the first 5 days. The laser treated animals had a better clinical outcome with a faster healing, and more granulation tissue. The quantity of blood vessels at both LG and CG were higher than in healthy mucosa. Regarding the therapeutic analysis, the severity of the mucositis in the TLG was always lower than TCG. TLG presented higher organization of the granulation tissue, parallel collagen fibrils, and increased angiogenesis. CONCLUSION: The results suggest that laser phototherapy had a positive effect in reducing mucositis severity, and a more pronounced effect in treating established mucositis.
Cynthia M França; Cristiane M França; Silvia C Núñez; Renato A Prates; Elisângela Noborikawa; Miriam R Faria; Martha S Ribeiro
Publication Detail:
Type:  Journal Article     Date:  2008-09-30
Journal Detail:
Title:  Journal of photochemistry and photobiology. B, Biology     Volume:  94     ISSN:  1011-1344     ISO Abbreviation:  J. Photochem. Photobiol. B, Biol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-29     Completed Date:  2009-03-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804966     Medline TA:  J Photochem Photobiol B     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  25-31     Citation Subset:  IM    
Professional Master Lasers in Dentistry, IPEN-CNEN/SP, Avenida Lineu Prestes, 2242, 05508-000 São Paulo, Brazil.
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MeSH Terms
Body Weight
Laser Therapy, Low-Level*
Stomatitis / pathology,  prevention & control*,  radiotherapy*

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