Document Detail


Low-intensity exercise training improves survival in Dahl salt hypertension.
MedLine Citation:
PMID:  16672837     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The present study examined whether exercise training could increase survival in a rodent model of salt-sensitive hypertension. METHODS: Male, inbred Dahl salt-sensitive rats arriving at 8 wk of age were randomly divided into a sedentary control group (N = 5) or an exercise-trained group (N = 8). Exercise training consisted of running 20 m.min(-1), 0% incline, 60 min.d(-1), 5 d.wk(-1) on a motorized driven treadmill. On arrival, animals were fed a low-salt diet (0.12% NaCl) during a 1-wk acclimatization period. At the end of this period, all rats were then fed a high-salt diet (7.8% NaCl) for the remainder of the study. Arterial systolic blood pressure (SBP) was measured via the tail-cuff method. RESULTS: Systolic blood pressure (SBP) measured on the low salt diet was similar between groups. After 2 wk of a high-salt diet, SBP was similarly significantly elevated in both control and exercise groups relative to the low salt diet. Kaplan-Meier analysis showed that exercise training increased survival (P < 0.02) with an approximate 30% increase in the mean days survived with exercise training (P < 0.02). CONCLUSION: These data suggest that exercise training is an important intervention for salt-sensitive hypertension and that the enhanced survival observed with exercise training appears to be independent of training-induced SBP lowering effects.
Authors:
Joseph R Libonati; John P Gaughan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  38     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-04     Completed Date:  2006-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  856-8     Citation Subset:  IM; S    
Affiliation:
Department of Kinesiology, Temple University, Philadelphia, PA 19122, USA. jlibonat@temple.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Diet, Sodium-Restricted*
Hypertension / physiopathology*
Male
Pennsylvania
Physical Conditioning, Animal / physiology*
Rats
Rats, Inbred Dahl
Sodium Chloride, Dietary
Survival Rate*
Chemical
Reg. No./Substance:
0/Sodium Chloride, Dietary

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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