| Low-intensity exercise training improves survival in Dahl salt hypertension. | |
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MedLine Citation:
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PMID: 16672837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The present study examined whether exercise training could increase survival in a rodent model of salt-sensitive hypertension. METHODS: Male, inbred Dahl salt-sensitive rats arriving at 8 wk of age were randomly divided into a sedentary control group (N = 5) or an exercise-trained group (N = 8). Exercise training consisted of running 20 m.min(-1), 0% incline, 60 min.d(-1), 5 d.wk(-1) on a motorized driven treadmill. On arrival, animals were fed a low-salt diet (0.12% NaCl) during a 1-wk acclimatization period. At the end of this period, all rats were then fed a high-salt diet (7.8% NaCl) for the remainder of the study. Arterial systolic blood pressure (SBP) was measured via the tail-cuff method. RESULTS: Systolic blood pressure (SBP) measured on the low salt diet was similar between groups. After 2 wk of a high-salt diet, SBP was similarly significantly elevated in both control and exercise groups relative to the low salt diet. Kaplan-Meier analysis showed that exercise training increased survival (P < 0.02) with an approximate 30% increase in the mean days survived with exercise training (P < 0.02). CONCLUSION: These data suggest that exercise training is an important intervention for salt-sensitive hypertension and that the enhanced survival observed with exercise training appears to be independent of training-induced SBP lowering effects. |
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Authors:
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Joseph R Libonati; John P Gaughan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 38 ISSN: 0195-9131 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-05-04 Completed Date: 2006-10-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
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Languages: eng Pagination: 856-8 Citation Subset: IM; S |
Affiliation:
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Department of Kinesiology, Temple University, Philadelphia, PA 19122, USA. jlibonat@temple.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diet, Sodium-Restricted* Hypertension / physiopathology* Male Pennsylvania Physical Conditioning, Animal / physiology* Rats Rats, Inbred Dahl Sodium Chloride, Dietary Survival Rate* |
| Chemical | |
Reg. No./Substance:
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0/Sodium Chloride, Dietary |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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