| Low-intensity exercise reverses chronic muscle pain in the rat in a naloxone-dependent manner. | |
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MedLine Citation:
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PMID: 16181935 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the effects of low-intensity exercise on chronic muscle pain and potential activation of the endogenous opioid system. DESIGN: Randomized placebo-controlled trial. SETTING: Animal laboratory. ANIMALS: Sixty-three male Sprague-Dawley rats. INTERVENTIONS: Rats performed a low-intensity exercise protocol for 5 consecutive days after the induction of chronic muscle pain. In a separate experiment, naloxone or saline was administered systemically before 5 low-intensity exercise sessions. MAIN OUTCOME MEASURE: Mechanical hyperalgesia was measured using von Frey filaments to determine the mechanical withdrawal threshold. RESULTS: Low-intensity exercise increased mechanical withdrawal threshold in the chronic muscle pain model. Naloxone attenuated the antihyperalgesic effects of low-intensity exercise. CONCLUSIONS: Low-intensity exercise reversed mechanical hyperalgesia in the chronic muscle pain model through activation of the endogenous opioid system. |
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Authors:
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Marie K Hoeger Bement; Kathleen A Sluka |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of physical medicine and rehabilitation Volume: 86 ISSN: 0003-9993 ISO Abbreviation: Arch Phys Med Rehabil Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-09-26 Completed Date: 2005-10-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985158R Medline TA: Arch Phys Med Rehabil Country: United States |
Other Details:
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Languages: eng Pagination: 1736-40 Citation Subset: AIM; IM |
Affiliation:
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Physical Therapy Department, Integrative Neuroscience Research Center, College of Health Sciences, Marquette University, Milwaukee, WI 53201, USA. mariehoeger.bement@marquette.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Area Under Curve Disease Models, Animal Male Muscular Diseases / physiopathology, rehabilitation* Naloxone / pharmacology* Pain / physiopathology, rehabilitation* Pain Measurement Physical Conditioning, Animal / methods* Probability Random Allocation Rats Rats, Sprague-Dawley Sensitivity and Specificity |
| Grant Support | |
ID/Acronym/Agency:
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F31 NS43962/NS/NINDS NIH HHS; K02 AR02201/AR/NIAMS NIH HHS; R01 NS 39734/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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465-65-6/Naloxone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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