Document Detail


Low-intensity exercise reverses chronic muscle pain in the rat in a naloxone-dependent manner.
MedLine Citation:
PMID:  16181935     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the effects of low-intensity exercise on chronic muscle pain and potential activation of the endogenous opioid system. DESIGN: Randomized placebo-controlled trial. SETTING: Animal laboratory. ANIMALS: Sixty-three male Sprague-Dawley rats. INTERVENTIONS: Rats performed a low-intensity exercise protocol for 5 consecutive days after the induction of chronic muscle pain. In a separate experiment, naloxone or saline was administered systemically before 5 low-intensity exercise sessions. MAIN OUTCOME MEASURE: Mechanical hyperalgesia was measured using von Frey filaments to determine the mechanical withdrawal threshold. RESULTS: Low-intensity exercise increased mechanical withdrawal threshold in the chronic muscle pain model. Naloxone attenuated the antihyperalgesic effects of low-intensity exercise. CONCLUSIONS: Low-intensity exercise reversed mechanical hyperalgesia in the chronic muscle pain model through activation of the endogenous opioid system.
Authors:
Marie K Hoeger Bement; Kathleen A Sluka
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of physical medicine and rehabilitation     Volume:  86     ISSN:  0003-9993     ISO Abbreviation:  Arch Phys Med Rehabil     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-26     Completed Date:  2005-10-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985158R     Medline TA:  Arch Phys Med Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1736-40     Citation Subset:  AIM; IM    
Affiliation:
Physical Therapy Department, Integrative Neuroscience Research Center, College of Health Sciences, Marquette University, Milwaukee, WI 53201, USA. mariehoeger.bement@marquette.edu
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Area Under Curve
Disease Models, Animal
Male
Muscular Diseases / physiopathology,  rehabilitation*
Naloxone / pharmacology*
Pain / physiopathology,  rehabilitation*
Pain Measurement
Physical Conditioning, Animal / methods*
Probability
Random Allocation
Rats
Rats, Sprague-Dawley
Sensitivity and Specificity
Grant Support
ID/Acronym/Agency:
F31 NS43962/NS/NINDS NIH HHS; K02 AR02201/AR/NIAMS NIH HHS; R01 NS 39734/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
465-65-6/Naloxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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