Document Detail

Low infectious morbidity after intensive chemotherapy and autologous peripheral blood progenitor cell transplantation in the outpatient setting for women with breast cancer.
MedLine Citation:
PMID:  11181116     Owner:  NLM     Status:  MEDLINE    
Autologous peripheral blood progenitor cell (PBPC) transplantation is increasingly employed in the outpatient setting, yet data on early complications following PBPC transplantation are scant. We evaluated 105 women with high-risk primary or metastatic breast cancer who were treated at a single institution during 1996--1997. The mean duration of neutropenia (absolute neutrophil count, <500 cells/mm(3)) was 7.5 days. Twenty-nine percent of women remained afebrile throughout the neutropenic period. Of the remaining 71%, most (64 of 75) had fever of unknown origin. Infections, mostly of mild severity, occurred in 34% of women; these infections included bacteremia due to gram-positive organisms, catheter site infection, cellulitis, pneumonia, oral candidiasis, herpes simplex virus infection, and vaginitis. Fifty percent of PBPC transplant recipients required hospital admission, usually because of persistent fever; the mean duration of hospitalization was 3 days. No deaths or serious adverse events occurred. Such reduced infectious morbidity may be a consequence of minimal oral and/or gastrointestinal mucositis associated with the conditioning regimen and broad-spectrum antimicrobial prophylaxis used for this patient population.
P H Chandrasekar; O C Abraham; J Klein; G Alangaden; G Chalasani; L Cassells; R Dansey; S Abella; C Karanes; W Peters; R Baynes
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Publication Detail:
Type:  Journal Article     Date:  2001-02-09
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  32     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-08-09     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  546-51     Citation Subset:  IM    
Division of Infectious Diseases, Department of Internal Medicine, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.
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MeSH Terms
Ambulatory Care*
Ambulatory Care Facilities
Anti-Infective Agents / therapeutic use
Antibiotic Prophylaxis
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Breast Neoplasms / therapy*
Carmustine / therapeutic use
Cisplatin / therapeutic use
Combined Modality Therapy
Cyclophosphamide / therapeutic use
Hematopoietic Stem Cell Transplantation*
Infection / epidemiology*,  microbiology,  virology
Middle Aged
Transplantation, Autologous
Reg. No./Substance:
0/Anti-Infective Agents; 154-93-8/Carmustine; 15663-27-1/Cisplatin; 50-18-0/Cyclophosphamide

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