Document Detail


Low infectious morbidity after intensive chemotherapy and autologous peripheral blood progenitor cell transplantation in the outpatient setting for women with breast cancer.
MedLine Citation:
PMID:  11181116     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autologous peripheral blood progenitor cell (PBPC) transplantation is increasingly employed in the outpatient setting, yet data on early complications following PBPC transplantation are scant. We evaluated 105 women with high-risk primary or metastatic breast cancer who were treated at a single institution during 1996--1997. The mean duration of neutropenia (absolute neutrophil count, <500 cells/mm(3)) was 7.5 days. Twenty-nine percent of women remained afebrile throughout the neutropenic period. Of the remaining 71%, most (64 of 75) had fever of unknown origin. Infections, mostly of mild severity, occurred in 34% of women; these infections included bacteremia due to gram-positive organisms, catheter site infection, cellulitis, pneumonia, oral candidiasis, herpes simplex virus infection, and vaginitis. Fifty percent of PBPC transplant recipients required hospital admission, usually because of persistent fever; the mean duration of hospitalization was 3 days. No deaths or serious adverse events occurred. Such reduced infectious morbidity may be a consequence of minimal oral and/or gastrointestinal mucositis associated with the conditioning regimen and broad-spectrum antimicrobial prophylaxis used for this patient population.
Authors:
P H Chandrasekar; O C Abraham; J Klein; G Alangaden; G Chalasani; L Cassells; R Dansey; S Abella; C Karanes; W Peters; R Baynes
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Publication Detail:
Type:  Journal Article     Date:  2001-02-09
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  32     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-08-09     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  546-51     Citation Subset:  IM    
Affiliation:
Division of Infectious Diseases, Department of Internal Medicine, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA. pchandrasekar@intmed.wayne.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Ambulatory Care*
Ambulatory Care Facilities
Anti-Infective Agents / therapeutic use
Antibiotic Prophylaxis
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Breast Neoplasms / therapy*
Carmustine / therapeutic use
Cisplatin / therapeutic use
Combined Modality Therapy
Cyclophosphamide / therapeutic use
Female
Hematopoietic Stem Cell Transplantation*
Humans
Infection / epidemiology*,  microbiology,  virology
Middle Aged
Morbidity
Transplantation, Autologous
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 154-93-8/Carmustine; 15663-27-1/Cisplatin; 50-18-0/Cyclophosphamide

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