| Low incidence of iris pigmentation and eyelash changes in 2 randomized clinical trials with unoprostone isopropyl 0.15%. | |
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MedLine Citation:
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PMID: 15288975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess whether iris color and eyelash changes occur with the use of unoprostone for 2 years. DESIGN: The 2 clinical trials described herein were prospective, randomized, double-masked, active-controlled, parallel group, multicenter studies. PARTICIPANTS: A total of 1131 patients with primary open-angle glaucoma or ocular hypertension participated in 2 clinical trials and received either unoprostone isopropyl 0.15% (659), timolol maleate 0.5% (331), or betaxolol hydrochloride 0.5% (141), 1 drop per eye twice daily for up to 24 months. METHODS: Color photographs (1:1 magnification) were taken of the iris and eyelid of each patient at baseline and at regular intervals thereafter through month 24 using a standardized camera system. Photography included 7 views of each eye plus a calibration photograph and a patient identification photograph, for a total of 16 photographs per patient per visit. Two independent (masked) readers subjectively compared baseline iris colors to subsequent visits. Side view photographs of the upper and lower eyelashes were used for the eyelash length analysis, with each having sufficient depth of field and a sufficient number of eyelashes in focus. Similarly, frontal eyelash views were used for the eyelash density analysis. MAIN OUTCOME MEASURES: Changes from baseline in iris color and eyelash length and density within and between treatment groups. RESULTS: Seven cases of iris color change (1.06%) were confirmed in patients treated with unoprostone for up to 24 months; no confirmed cases were reported in the timolol or betaxolol groups. In the unoprostone group, cases of iris color change were confirmed at months 12 (1 case), 18 (2 cases), and 24 (4 cases). No clinically relevant differences were observed among treatment groups for changes from baseline in eyelash length or density. CONCLUSION: Although iris hyperpigmentation and abnormal eyelash changes may occur after treatment with unoprostone, the incidence of these events appears to be low in the 2-year clinical study. |
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Authors:
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Bernard E McCarey; Barry M Kapik; Frances E Kane; |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Ophthalmology Volume: 111 ISSN: 0161-6420 ISO Abbreviation: Ophthalmology Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-03 Completed Date: 2004-08-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802443 Medline TA: Ophthalmology Country: United States |
Other Details:
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Languages: eng Pagination: 1480-8 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antihypertensive Agents / adverse effects*, therapeutic use Betaxolol / adverse effects, therapeutic use Dinoprost / adverse effects*, analogs & derivatives*, therapeutic use Double-Blind Method Eye Color / drug effects* Eyelashes / drug effects* Female Glaucoma, Open-Angle / drug therapy* Hair Color / drug effects* Humans Hyperpigmentation / chemically induced*, epidemiology Incidence Intraocular Pressure / drug effects Iris / drug effects Male Middle Aged Ocular Hypertension / drug therapy Ophthalmic Solutions / adverse effects, therapeutic use Photography Timolol / adverse effects, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Ophthalmic Solutions; 26839-75-8/Timolol; 551-11-1/Dinoprost; 63659-18-7/Betaxolol; 69553-75-9/isopropyl unoprostone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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