| Low incidence of hypertensive disorders of pregnancy in women treated with spiramycin for toxoplasma infection. | |
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MedLine Citation:
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PMID: 16487228 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Toxoplasma infection in pregnancy is usually treated with long-term administration of the macrolide spiramycin to prevent fetal malformations. We had empirically observed that treated patients seldom developed pregnancy-induced hypertension (PIH), a common and severe disorder of pregnancy whose aetiology and pathogenesis are still debated. Some clinical and experimental data suggest that infection could play a role in its development. METHODS: To test this hypothesis, we studied a cohort of 417 pregnant women treated with spiramycin because of seroconversion for Toxoplasma gondii and 353 low-risk women who did not take any antibiotic during pregnancy. PIH was defined as blood pressure>140/90 mmHg on two or more occasions, occurring after 20 weeks of gestational age. RESULTS: Seventeen (5.2%) women in the control group developed PIH compared with two (0.5%) in the case group. The odds of developing the disease were significantly lower in the treated subjects (odds ratio=0.092, 95% confidence interval 0.021, 0.399; P<0.001). CONCLUSIONS: Our results suggest that antibiotic treatment during pregnancy can reduce the incidence of PIH, thus opening new perspectives in its prevention and therapy. |
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Authors:
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T Todros; P Verdiglione; G Oggè; D Paladini; P Vergani; S Cardaropoli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 61 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-02-20 Completed Date: 2006-09-01 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 336-40 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, University of Turin, Turin, Italy. tullia.todros@unito.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Bacterial Agents / therapeutic use* Case-Control Studies Cohort Studies Female Humans Hypertension, Pregnancy-Induced / prevention & control* Pre-Eclampsia / prevention & control Pregnancy Pregnancy Complications, Infectious / drug therapy* Spiramycin / therapeutic use* Toxoplasmosis / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 8025-81-8/Spiramycin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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