Document Detail


Low incidence of hepatotoxicity in a cohort of HIV patients treated with lopinavir/ritonavir.
MedLine Citation:
PMID:  16103779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We describe the hepatotoxicity encountered in a cohort of HIV-positive patients treated with lopinavir/ritonavir. We used the database from the SCOLTA project, an on-line pharmacovigilance programme involving 25 Italian infectious disease centres. A total of 755 patients were followed, over a mean observation period of 16 months. The incidence of severe events was low despite the high prevalence of patients co-infected with hepatitis virus at enrollment.
Authors:
Paolo Bonfanti; Elena Ricci; Giovanni Penco; Giancarlo Orofino; Teresa Bini; Claudio Sfara; Sebastiano Miccolis; Giovanni Cristina; Tiziana Quirino;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AIDS (London, England)     Volume:  19     ISSN:  0269-9370     ISO Abbreviation:  AIDS     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-16     Completed Date:  2006-04-04     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  1433-4     Citation Subset:  IM; X    
Affiliation:
I Divisione di Malattie Infettive, Ospedale Luigi Sacco, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Drug-Induced Liver Injury*
Female
HIV Infections / drug therapy*
HIV Protease Inhibitors / adverse effects*
Hepatitis B, Chronic / complications
Hepatitis C, Chronic / complications
Humans
Incidence
Italy / epidemiology
Liver Diseases / epidemiology
Male
Middle Aged
Product Surveillance, Postmarketing
Pyrimidinones / adverse effects*
Ritonavir / adverse effects*
Chemical
Reg. No./Substance:
0/HIV Protease Inhibitors; 0/Pyrimidinones; 0/Ritonavir; 192725-17-0/lopinavir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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