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Low incidence of cardiac events in statin-administered patients in CAG study.
MedLine Citation:
PMID:  19556725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: The effect of statins in preventing cardiac events in Japanese coronary artery disease (CAD) patients was studied in a retrospective investigation of 148 patients diagnosed with CAD by coronary angiography (CAG). METHODS: Sixty-five patients received statins within 2 weeks after CAG, and 83 patients did not receive statins after CAG. RESULTS: In the statin group, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were reduced significantly with statin administration (p<0.01). In the non-statin group, baseline levels of TC, LDL-C and high-density lipoprotein cholesterol were not changed significantly at the end of the follow-up period. As for the effect of statin in preventing cardiac events, the incidence of cardiac events was significantly lower (p<0.0003) in the statin group (n=5: 8%) than in the non-statin group (n=28: 34%). In subanalysis of 37 patients whose TC at the time of initial CAG was less than 200 mg/dL, none of the statin group (n=17) suffered a cardiac event. This was significantly lower than the incidence of cardiac events in the non-statin group (n=5: 25%; p<0.05). CONCLUSION: The present study demonstrated that lowering LDL-C of Japanese CAD patients by statin administration is effective to prevent cardiac events, particularly, a second percutaneous coronary intervention (PCI) for restenosis of a coronary artery following the initial PCI whether or not these patients had hypercholesterolemia.
Authors:
Tomoaki Saeki; Nagahiko Sakuma; Kiyoshi Hayakawa; Kenichi Itou; Kazuaki Wakami; Nozomu Tamai; Genjiro Kimura
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Publication Detail:
Type:  Journal Article     Date:  2009-06-25
Journal Detail:
Title:  Journal of atherosclerosis and thrombosis     Volume:  16     ISSN:  1880-3873     ISO Abbreviation:  J. Atheroscler. Thromb.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-07-29     Completed Date:  2009-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506298     Medline TA:  J Atheroscler Thromb     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  172-8     Citation Subset:  IM    
Affiliation:
Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Angioplasty, Transluminal, Percutaneous Coronary
Cholesterol / blood
Cholesterol, LDL / blood
Coronary Angiography
Coronary Artery Disease / drug therapy*,  mortality,  radiography
Coronary Restenosis / prevention & control
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage*
Incidence
Japan
Male
Middle Aged
Myocardial Infarction / prevention & control
Retrospective Studies
Survival Rate
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Cholesterol, LDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Triglycerides; 57-88-5/Cholesterol

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