| Low incidence of cardiac events in statin-administered patients in CAG study. | |
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MedLine Citation:
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PMID: 19556725 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The effect of statins in preventing cardiac events in Japanese coronary artery disease (CAD) patients was studied in a retrospective investigation of 148 patients diagnosed with CAD by coronary angiography (CAG). METHODS: Sixty-five patients received statins within 2 weeks after CAG, and 83 patients did not receive statins after CAG. RESULTS: In the statin group, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were reduced significantly with statin administration (p<0.01). In the non-statin group, baseline levels of TC, LDL-C and high-density lipoprotein cholesterol were not changed significantly at the end of the follow-up period. As for the effect of statin in preventing cardiac events, the incidence of cardiac events was significantly lower (p<0.0003) in the statin group (n=5: 8%) than in the non-statin group (n=28: 34%). In subanalysis of 37 patients whose TC at the time of initial CAG was less than 200 mg/dL, none of the statin group (n=17) suffered a cardiac event. This was significantly lower than the incidence of cardiac events in the non-statin group (n=5: 25%; p<0.05). CONCLUSION: The present study demonstrated that lowering LDL-C of Japanese CAD patients by statin administration is effective to prevent cardiac events, particularly, a second percutaneous coronary intervention (PCI) for restenosis of a coronary artery following the initial PCI whether or not these patients had hypercholesterolemia. |
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Authors:
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Tomoaki Saeki; Nagahiko Sakuma; Kiyoshi Hayakawa; Kenichi Itou; Kazuaki Wakami; Nozomu Tamai; Genjiro Kimura |
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Publication Detail:
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Type: Journal Article Date: 2009-06-25 |
Journal Detail:
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Title: Journal of atherosclerosis and thrombosis Volume: 16 ISSN: 1880-3873 ISO Abbreviation: J. Atheroscler. Thromb. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-07-29 Completed Date: 2009-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506298 Medline TA: J Atheroscler Thromb Country: Japan |
Other Details:
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Languages: eng Pagination: 172-8 Citation Subset: IM |
Affiliation:
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Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary Cholesterol / blood Cholesterol, LDL / blood Coronary Angiography Coronary Artery Disease / drug therapy*, mortality, radiography Coronary Restenosis / prevention & control Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage* Incidence Japan Male Middle Aged Myocardial Infarction / prevention & control Retrospective Studies Survival Rate Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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